Background: Female genital mutilation/cutting (FGM/C) is applied to more than 130 million women in the world with long-term complications of pain, dyspareunia, difficulty in urination, recurrent urinary tract infection, vesicovaginal fistula, and obstetric morbidities. The authors present a case of spontaneous bladder rupture following vaginal delivery in a genital mutilated pregnant woman, which has not been reported in the literature previously. Case Report: A 31-year old age primigravid woman presented on postpartum 6^th day with abdominal distention, ileus, dyspnea, and acute renal failure. After physical and radiological examination with laboratory analysis the initial diagnosis was intra-abdominal sepsis. During laparotomy, disseminated abscess formation and massive urinary leakage from ruptured bladder wall was observed. After bladder repair, open abdomen procedure was performed to control abdominal infection. Vacuum- assisted closure therapy was applied as a temporary abdominal closure method. The patient was discharged from the hospital with no complications on the 14^th day. Conclusion: This case report shows that genital mutilation can lead to genitourinary system injuries and is one of the etiologic factors of spontaneous bladder rupture during vaginal delivery.