IMR Press / CEOG / Volume 44 / Issue 6 / DOI: 10.12891/ceog3498.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Effects of levothyroxine on pregnancy outcomes and caveolin-1 expression in rat models of thyroid dysfunction
Show Less
1 Shenzhen Maternal and Children Health Care Hospital of Southern Medical University, Shenzhen, China
2 Obstetrics Department, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Clin. Exp. Obstet. Gynecol. 2017, 44(6), 847–850; https://doi.org/10.12891/ceog3498.2017
Published: 10 December 2017
Abstract

To investigate the effect of thyroid hormone levothyroxine (L-T4 ) on pregnancy outcomes and expression of caveolin-1 in rat models of thyroid dysfunction. Materials and Methods: One hundred Wistar rats (SPE grade, 60 female and 40 male) were randomly divided into three groups of control, model (hypothyroidism), and treatment (hypothyroidism + therapy with L-T4 ) groups. Pregnant rats were investigated for pregnancy outcomes (litter size, number of dead fetus, placental index, body weight and length, and tail length of neonatal rat). Expression of caveolin-1 in placenta was analyzed using qRT- PCR and Western blot. Results: The modeling success rate was 75%. Investigations showed that the litter size, number of dead fetus, placental index, body and length, and tail length of neonatal rat in the models were significantly lower than those in control rats (p < 0.05), and significantly different from those in the treatment group (p < 0.05) except for the tail length (p > 0.05). The expression level of caveolin-1 in placenta was significantly higher in models than that in control (p < 0.05). Conclusion: Propylthiouracil (PTU) can successfully induce hypothyroidism in rat and hypothyroidism can seriously hinder the pregnancy process, resulting in developmental disorders in fetal rat.
Keywords
Thyroid hormone
Thyroid function
Caveolin-1
Gene expression
Pregnancy fate
Share
Back to top