IMR Press / CEOG / Volume 44 / Issue 5 / DOI: 10.12891/ceog3744.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Uterus and myoma histomorphology
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1 Ankara University, Institute of Health, Neuroscience Department, Sihhiye, Ankara, Turkey
2 Department of Anatomy, Faculty of Medicine, Gazi University, Beşevler, Ankara, Turkey
3 Department of Histology and Embryology, Faculty of Medicine, Gazi University, Beşevler, Ankara, Turkey
4 Department of Pathology, Faculty of Medicine, Gazi University, Beşevler, Ankara, Turkey
Clin. Exp. Obstet. Gynecol. 2017, 44(5), 710–715; https://doi.org/10.12891/ceog3744.2017
Published: 10 October 2017
Abstract

Objective: Uterine fibroids, or leiomyomas are common benign neoplasms of the myometrium. These neoplasms are composed of large amounts of extracellular matrix and disarrayed smooth muscle tissue. The aim of this study was to examine the histomorphological differences between myoma uteri and uterus. Materials and Methods: Thickness of muscle fascicles and collagen fibers, and vascular and histological structures were evaluated by using morphometric, histomorphologic and immunohistochemical analyses, and findings represented by using three-dimensional (3D) modeling. The authors used a light microscope and photos were captured using a specific program for analysis. Light micrographs were assembled into 3D images. Results and Conclusion: Histological and 3D findings demonstrated that the muscle fiber is a vital part of the myometrium and loss of its contractility indicates a significant deviation from the uterine structure.
Keywords
Histomorphology
Immunohistochemistry
Three-dimensional modeling
Uterine myoma
Uterus
Leiomyomas
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