Aims: To explore the perinatal and neonatal outcomes of patients with heart diseases. Materials Methods: Retrospective case control analysis was carried out among 10,527 deliveries, 188 pregnancies complicated by cardiovascular disease (CVD) compared with pregnancies without CVD for obstetric outcomes from January 2000 to December 2012. The effect of cardiac functional classification (NHYA) on maternal and neonatal complications was explored. Results: The incidence of CVD in pregnancy was 1.78%. About 80.3% had rheumatic heart disease (RHD). Maternal and neonatal mortality rate was 1.06% and 2.13 %, respectively. The obstetric outcomes of women in NHYA class I / II were similar to normal group. Vaginal delivery was the preferred way of birth unless deterioration of cardiac functions as in the cases of NHYA class III/IV. NHYA class III/IV had significantly decreased birth weight, premature birth, and increased maternal-neonatal mortality (p < 0.05). Conclusion: RHD is still prevalent. The cardiac functional capacity predicts maternal and neonatal outcomes.