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Original Research
Soy isoflavones, inulin, calcium, and vitamin D3 in post-menopausal hot flushes: an observational study
A. Cianci1, N. Colacurci2, A. M. Paoletti3, A. Perino4, E. Cicinelli5, S. Maffei6, M. Di Martino7, R. Daguati7, M. Stomati8, M. Pilloni3, S. G. Vitale1, E. Ricci7, F. Parazzini7,*
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1
University of Catania, Catania
2
University of Naples Federico II, Naples
3
University of Cagliari, Cagliari
4
University of Palermo, Palermo
5
University of Bari Aldo Moro, Bari
6
CNR Pisa, Institute of Clinical Physiology of CNR Pisa, Pisa
7
University of Milan, Department of Clinical and Community Sciences, University of Milan, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan
8
«D. Camberlingo» Hospital, Francavilla Fontana, Brindisi, A.S.L. Brindisi Presidio Ospedaliero Camberlingo, Francavilla Fontana (BR) (Italy)
Clin. Exp. Obstet. Gynecol. 2015, 42(6), 743–745;
https://doi.org/10.12891/ceog2008.2015
Published: 10 December 2015
Abstract
Purpose of investigation: To evaluate the effect of soy isoflavones and inulin (SII) on hot flushes (HF) and quality of life in a clinical setting, the authors conducted an observational study. Materials and Methods: The authors performed an observational, prospective, multicentric study on women in peri-/post-menopause treated or untreated with a product present on the Italian market, consisting in a mixture of calcium (500 mg), vitamin D3 (300 IU), inulin (3 g) and soy isoflavones (40 mg). Results:A total of 135 patients, 75 (55.6%) in the SII group and 60 (44.4%) in the untreated group entered the study. After three months, the mean number of HF declined of 2.8 (SD 3.7) in the SII group and 0.0 in the untreated one. The corresponding values after six months were –3.7 (SD 2.7) in the SII group and –0.9 (SD 5.3) in the control group (p = 0.02). Conclusion: This observational trial suggests a possible beneficial effect of a dietary soy supplement containing 40 mg of isoflavone/day plus inulin in the management of menopausal symptoms such as hot flashes.
Keywords
Menopause
Hot flushes
Inulin
Isoflavone