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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Evidence that the main adverse effect of ganirelix on pregnancy and implantation rates is on the embryo rather than the endometrium
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertiliry, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2011, 38(4), 326–327;
Published: 10 December 2011
Abstract
Purpose: To compare pregnancy rates following the transfer of thawed frozen embryos according to the type of GinRH antagonist oragonist used during controlled ovarian hyperstimulation (COH). Methods: Retrospective review of frozen embryo transfers accordingto whether a GnRH agonist or antagonist was used. Furthermore to determine if a specific antagonist/agonist resulted in higher pregnancy rates than the other. Results: The pregnancy rates in two different age categories were similar whether the COH regimen usedthe GnRH agonist leuprolide acetate or the GnRH antagonist cetrorelix. However, lower pregnancy rates were found with the GnRH antagonist ganirelix. Conclusions: These data reached similar conclusions as was found comparing these three agents in fresh embryotransfer.
Keywords
GnRH agonist
GnRH antagonist
Frozen embryo transfer