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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Induction of plasminogen activators in pregnant women with Toxoplasma gondii infection
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1
Institute of Medicine, Chung Shan Medical University
2
Department of Parasitology, Chung Shan Medical University
3
Clinical Laboratory, Chung Shan University Hospital, Taiwan (ROC)
Clin. Exp. Obstet. Gynecol. 2011, 38(4), 342–346;
Published: 10 December 2011
Abstract
Objective: To determine whether plasminogen activators (PAs) are involved in the pathologic process of toxoplasmosis. Materials and methods: Out of 220 pregnant women the study included 26 with a diagnosis of toxoplasmosis: six based on seropositivity for Toxoplasma gondii IgM and 20 based on seropositivity for T. gondii IgG. We measured serum activities and protein levels of PAs by casein zymography and Western blotting, respectively. Results: Serum PAs were higher in healthy pregnant women than in their healthy nonpregnant counterparts. Furthermore, serum PAs were significantly higher in pregnant women infected with T. gondii than in their healthy counterparts. Conclusion: PAs participate in the pathogenesis of toxoplasmosis in pregnant women and maybe useful markers of T. gondii infection.
Keywords
Plasminogen activators
Pregnancy
Toxoplasma gondii
tPA
uPA