IMR Press / CEOG / Volume 36 / Issue 1 / pii/1630635163304-711157866

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The accuracy of frozen section analysis at hysterectomy in patients with atypical endometrial hyperplasia
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1 Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology
2 Department of Pathology, Hacettepe University Faculty of Medicine, Ankara (Turkey)
Clin. Exp. Obstet. Gynecol. 2009, 36(1), 31–34;
Published: 10 March 2009

Purpose of investigation: To evaluate the accuracy of frozen section analysis in patients with atypical endometrial hyperplasia. Methods: Women who underwent hysterectomy with frozen section analysis for atypical endometrial hyperplasia were identified. Frozen section evaluation aimed to give information about the presence of malignancy. Also, myometrial or cervical involvement was assessed in cases with malignancy to reveal the need for staging. Final pathological evaluation results were compared with intraoperative frozen section analyses. Results: Twelve patients (34.3%) had endometrial cancer on final pathologic examination and eight required a staging procedure due to either myometrial invasion or cervical involvement; 75% of patients with endometrial cancer were successfully detected by frozen section analysis. Moreover, among women with cancer, frozen section examination revealed 75% of cases who required surgical staging. Conclusion: Frozen section analysis of hysterectomy specimens in patients with atypical endometrial hyperplasia is necessary to determine the presence of cancer and the need for surgical staging.
Frozen section
Endometrial hyperplasia
Atypical endometrial hyperplasia
Endometrial cancer
Surgical staging
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