IMR Press / CEOG / Volume 21 / Issue 4 / pii/1994043

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Gestosis and fetal rejection: immunopathogenetic role of HLA-DR

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1 Department of Obstetrics and Gynecology, University of Pisa, Italy
2 Institute of Pathologic Anatomy, University of Pisa, Italy
3 Immunohemathology O.U., S. Chiara Hospital - Pisa, Italy
Clin. Exp. Obstet. Gynecol. 1994, 21(4), 228–230;
Published: 10 December 1994
Abstract

In this study we faced the problem of etiopathogenesis of EPH Gestosis, focusing our attention on the role of immunitary aspects in determining its onset. We typed HLA-DR in 20 couples with gestosic patient and in 20 control couples. Blood samples were taken into heparin-treated test tubes, from all the couples and HLA typed through standard lymphotoxicity technique in accordance with Terasaky (1). Our results in couples with a gestosic patient, showed homozygosis in 65% of patients and in 70% of partners; in 35% of cases homozygosis was present in both partners, and these were the most severe cases. It is also worth mentioning that in all the couples with gestosic patient, at least one of the partners resulted homozygotic. Homozygosis would therefore represent a predisposing factor in the etiopathogenesis of gestosis, and pre-conception HLA-DR typing of the couple could prove to be a valid alarm signal for gestosis risk.

Keywords
Gestosis
HLA-DR
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