IMR Press / CEOG / Volume 12 / Issue 3-4 / pii/1634257754618-174993066

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Increase in glycosylated hemoglobin (HBA1c) in menopausal women treated with vaginal estrogen cream
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1 Dept. of Obst. Gyn. Special Outpatient Clinics Mishmar Hayarden - Dan District, Tel Aviv University (Israel)
2 Biochemical Laboratory - Dan District
3 Dept. of Statistics - Tel Aviv University (Israel)
Clin. Exp. Obstet. Gynecol. 1985, 12(3-4), 72–75;
Published: 10 September 1985

In a group of 20 menopausal women 45-78 years old (mean age 62.4), with typical symptoms such as dryness of the vagina, urinary disturbances, "mental" symptoms, or vasomotor disturbances, treated with topical vaginal estrogen cream, we examined the glucose tolerance, as expressed by Gycohemoglobin (HbA1c) and GTT. Estrogen, well absorbed by the vaginal epithelium gives rise to the HbA1c from a mean of 6.4% to 14.78% (P less than 0.0001). The GTT too shows a glucose intolerance, but never a frank diabetic picture. In four cases in which the cardinal symptoms were vasomotor disturbances (hot flushes, profuse sweating) the addition of oral clonidine hydrochlorate (Clonirit) to the vaginal estrogen cream, leads to the relief of symptoms. The Glycohemoglobin test is fast, inexpensive and easy to perform in every laboratory, giving the possibility of discovering an unknown or borderline diabetes.
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