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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
The effect of a prostaglandin synthetase inhibitor, indomethacin, on excessive uterine bleeding
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1
Department of Obstetrics and Gynecology, Hadassah University, Medical Center, Jerusalem, Israel
2
Department of Medical Ecology, Hadassah University, Medical Center, Jerusalem, Israel
Clin. Exp. Obstet. Gynecol. 1985, 12(3-4), 60–63;
Published: 10 September 1985
Abstract
Indomethacin, a prostaglandin synthetase inhibitor given to 94 women suffering from functional menorrhagia, IUD's and sub mucous fibroid related bleeding, reduced menstrual loss and duration of menstruation in 70 patients (74.5 percent). A significant decrease in duration of menstruation of 2.1 days was obtained in the responding group. In functional bleeding, the mean decrease was 1.7 days, in IUD’s related menorrhagia 2.9 days and in menorrhagia due to submucous fibroids 2 days. Age, parity and duration of menstruation before treatment had no significant effect on the response or reduction of duration of bleeding. The medication was discontinued only in two patients because of minor gastronntestinal symptoms.
Keywords
Menorrhagia
Lndomethacin
Functional Bleeding
IUD related Bleeding
Sumucous Fibroids