IMR Press / CEOG / Volume 46 / Issue 4 / DOI: 10.12891/ceog4781.2019
Open Access Original Research
Pregnancy outcome of recurrent spontaneous abortion in Wilson’s disease after decoppering therapy
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1 Center for Reproductive Medicine, Prenatal Diagnosis Center, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China
2 Anhui University of Traditional Chinese Medicine, Hefei, China
3 Department of Neurology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China
*Correspondence: (HUI HAN)
†Contributed equally.
Clin. Exp. Obstet. Gynecol. 2019, 46(4), 626–629;
Published: 10 August 2019

Purpose of Investigation: To report pregnancy outcome after decoppering therapy in patients with recurrent spontaneous abortion (RSA) and Wilson’s disease (WD). Materials and Methods: In a retrospective study, 12 WD patients who suffered from RSA were treated with dimercaptosuccinic acid and zinc gluconate. The average daily dose of dimercaptosuccinic acid and zinc gluconate was 1.00 and 1.68 grams, respectively. Dimercaptosuccinic acid was discontinued, while zinc gluconate was continued during pregnancy. The primary clinical outcomes were the pregnancy outcome after decoppering therapy and the mean age at diagnosis. Results: Six patients conceived at least once after treatment. Five of them had successful pregnancies with seven healthy live births. Mean age at diagnosis was significantly lower in patients who delivered healthy babies than in those who failed to conceive. Conclusions: Decoppering therapy is efficacious in reversing the pregnancy outcome of RSA in patients with WD, especially in the women who are diagnosed at young age. Age at diagnosis is an important risk factor that affects the pregnancy outcome in these patients.

Pregnancy outcome
Recurrent spontaneous abortion
Wilson’s disease
Decoppering therapy
Figure 1.
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