Dear Colleagues,

It is our great pleasure and honor to announce this Special Issue on “Inflammation and Cardiovascular Disease”. 

Despite improvements in treatment, cardiovascular disease (CVD) remains the leading cause of death worldwide. This Special Issue will focus on the latest advances in understanding the mechanisms, pathways and mediators that link inflammation to CVD with an emphasis on topics related to molecular diagnosis, biomarkers and pharmacologic therapy of CVD. It is well-established that physiological and pathophysiological processes involved in CVD are affected by systemic oxidative stress and sustained low-grade inflammation. Inflammation affects multiple cell types involved in CVD including macrophages, endothelium and smooth muscle. However, studies targeting inflammation as a means of reducing residual CVD risk have been disappointing and this has left a knowledge gap in need of resolution. A key aim of this issue will be to examine molecular mechanisms that are involved in the crosstalk between inflammation and CVD.

We welcome original clinical or pre-clinical research papers and basic research papers. Reviews that identify problems or challenges, present a dedicated overview or provide solutions or prospects will also be considered.

We look forward to receiving your original research or review articles.

Allison B. Reiss and Joshua De Leon

Guest Editors