Background: A potential relationship between oral inflammation and
cardiovascular disease has been proposed; however, the impact of cardiovascular
disease on implant restoration remains unclear. This systematic review aims to
assess the relationship between peri-implantitis and cardiovascular disease based
on review of data obtained through observational studies. Materials and
Methods: An extensive systematic literature search was performed using the
PubMed/MEDLINE, Scopus, Web of Science and Cochrane Library databases. Studies
published in English language up to June 2022 were conducted in accordance with
PRISMA guidelines. These efforts identified 230 unique publications and, after
selection, five studies were included in this meta-analysis. The Newcastle-Ottawa
Scale table was used for literature quality assessment. A fixed-effect model was
selected and RevMan software version 5.3 was used to identify the origin of the
outcomes of the meta-analysis. Finally, results were reported through the PRISMA
statement. Results: This meta-analysis found that in implant restoration
the incidence of peri-implantitis in patients with cardiovascular disease was
higher than those without cardiovascular disease (Risk ratio (RR) = 1.12; 95%
CI: 1.02–1.23; z = 2.34; p
