IMR Press / RCM / Volume 23 / Issue 9 / DOI: 10.31083/j.rcm2309317
Open Access Original Research
Research Landscape on Atherosclerotic Cardiovascular Disease and Inflammation: A Bibliometric and Visualized Study
Wende Tian1,2,3,†Tai Zhang1,2,4,†Xinyi Wang1,2,3Jie Zhang3,5Jianqing Ju1,3,*Hao Xu1,3,*
Show Less
1 Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091 Beijing, China
2 Graduate School, China Academy of Chinese Medical Sciences, 100700 Beijing, China
3 National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091 Beijing, China
4 Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091 Beijing, China
5 Graduate School, Beijing University of Chinese Medicine, 100029 Beijing, China
*Correspondence: (Jianqing Ju); (Hao Xu)
These authors contributed equally.
Academic Editor: Gianluca Rigatelli
Rev. Cardiovasc. Med. 2022, 23(9), 317;
Submitted: 30 May 2022 | Revised: 7 July 2022 | Accepted: 27 July 2022 | Published: 14 September 2022
(This article belongs to the Special Issue Inflammation and Cardiovascular Diseases)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: The atherosclerotic cardiovascular disease (ASCVD) is a major killer and health care burden worldwide. Atherosclerosis, the common pathological foundation, has been associated with inflammation over the past few years. Some promising results also have emerged suggesting the role of targeting inflammation as a potential therapeutic option to reduce cardiovascular events. In light of the pathogenic role that inflammation plays in ASCVD, we propose to evaluate the worldwide research architecture for ASCVD and inflammation using bibliometric analysis. Methods: A search of the Web of Science Core Collection of Clarivate Analytics was performed for articles in the field published between 2012 and 2022. The number of publications per year has been visualized using GraphPad Prism through time. CiteSpace and VOSviewer were used to generate knowledge maps about the collaboration of countries, institutions, and authors, and to represent the landscape on ASCVD and inflammation research as well as to reveal current foci. Results: There were a total of 19,053 publications examined in this study. The most publications came from China (6232, 32.71%). Capital Med Univ was the most productive institution (410, 2.15%). Christian Weber published the greatest number of articles (75, 0.39%). PloS one was identified as the most prolific journal (706, 3.71%). Circulation was the most co-cited journal (13276, 2.81%). Keywords with the ongoing strong citation bursts were “nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome”, “intestinal microbiota”, “exosome”, “lncRNAs”, etc. Conclusions: It can be shown that ASCVD and inflammation research benefited from manuscripts that had a high impact on the scientific community. Asian, European and North American countries dominated in the field in terms of quantitative, qualitative and collaborative parameters. The NLRP3 inflammasome, gut microbiota and trimethylamine N-oxide, autophagy, lncRNAs, exosomes, and nuclear factor erythroid 2-related factor 2 were described to be hot themes in the field.

atherosclerotic cardiovascular~disease
Fig. 1.
81874412/ National Natural Science Foundation of China
82074215/ National Natural Science Foundation of China
ZYYCXTD-C-202007/ Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine
CI2021A00917/ China Academy of Chinese Medical Sciences Innovation Fund
Back to top