IMR Press / RCM / Volume 4 / Issue S1 / pii/1561439350005-991592408

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Beyond Serum Creatinine: Defining the Patient with Renal Insufficiency and Why?
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1 Divisions of Cardiology, Nutrition, and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI
Rev. Cardiovasc. Med. 2003, 4(S1), 2–6;
Published: 20 January 2003
Chronic kidney disease is the most important factor in predicting adverse short- and long-term outcomes after percutaneous coronary intervention. Most studies of cardiovascular outcomes have found that a break point for the development of radiocontrast nephropathy (RCN), later restenosis, recurrent myocardial infarction, congestive heart failure, and cardiovascular death, occurs below an estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73 m2, which roughly corresponds to a serum creatinine (Cr) of > 1.5 mg/dL in the general population. Renal dysfunction is accurately recognized by calculating the eGFR from the age, serum creatinine, gender, race, and weight, and not from the serum creatinine alone. The pathogenesis of RCN goes beyond serum Cr and involves a unique vascular pathobiology that interrelates both the renal and cardiovascular disease outcomes.
Cardiovascular disease
Chronic kidney disease
Acute renal failure
Radiocontrast nephropathy
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