IMR Press / RCM / Volume 25 / Issue 2 / DOI: 10.31083/j.rcm2502060
Open Access Review
Antithrombotic Therapy Following Structural Heart Disease Interventions: Current Status and Future Directions
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1 Cardiology Department, Nicosia General Hospital, 2029 Nicosia, Cyprus
2 Cardiology Department, Limassol General Hospital, 3304 Nicosia, Cyprus
3 Department of Internal Medicine, Cardiology Clinic, Kantonsspital Baden, 5404 Baden, Switzerland
*Correspondence: (Andreas Mitsis)
Rev. Cardiovasc. Med. 2024, 25(2), 60;
Submitted: 8 October 2023 | Revised: 25 November 2023 | Accepted: 7 December 2023 | Published: 5 February 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Interventions in structural heart disease cover many catheter-based procedures for congenital and acquired conditions including valvular diseases, septal defects, arterial or venous obstructions, and fistulas. Among the available procedures, the most common are aortic valve implantation, mitral or tricuspid valve repair/implantation, left atrial appendage occlusion, and patent foramen ovale closure. Antithrombotic therapy for transcatheter structural heart disease interventions aims to prevent thromboembolic events and reduce the risk of short-term and long-term complications. The specific approach to antithrombotic therapy depends on the type of intervention and individual patient factors. In this review, we synopsize contemporary evidence on antithrombotic therapies for structural heart disease interventions and highlight the importance of a personalized approach. These recommendations may evolve over time as new evidence emerges and clinical guidelines are updated. Therefore, it’s crucial for healthcare professionals to stay updated on the most recent guidelines and individualize therapy based on patient-specific factors and procedural considerations.

atrial appendage
atrial fibrillation
mitral valve
transcatheter aortic valve implantation
patent foramen ovale
Fig. 1.
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