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- Academic Editor
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†These authors contributed equally.
§These authors contributed equally.
Background: Some individuals who maintain desirable low-density
lipoprotein cholesterol (LDL-C) levels still experience the progression of
atherosclerosis, which may eventually lead to cardiovascular events.
Non-high-density lipoprotein cholesterol (non-HDL-C) levels are quantified to
assess residual risk in statin-treated patients with coronary heart disease. The
study aimed to estimate the predictive performance of discordance between
non-HDL-C and LDL-C on clinical prognosis in statin-treated patients with
previous coronary artery bypass grafting (CABG). Methods: 468
statin-treated patients with previous CABG undergoing percutaneous coronary
intervention (PCI) as a secondary coronary treatment due to acute coronary
syndrome (ACS) were retrospectively enrolled in this study. The definition of
major adverse cardiovascular events (MACEs) was a composite endpoint of
cardiovascular death, recurring myocardial infarction, and a need for repeat
revascularization. Cox proportional hazards modeling, restricted cubic splines
regression, and discordance analysis were conducted to the association between
all lipid parameters and the occurrence of MACEs. Discordant values were defined
as LDL-C concentrations