IMR Press / RCM / Volume 24 / Issue 12 / DOI: 10.31083/j.rcm2412340
Open Access Review
Macrophage in Sporadic Thoracic Aortic Aneurysm and Dissection: Potential Therapeutic and Preventing Target
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1 Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, 200032 Shanghai, China
2 Cardiac Intensive Care Center, Zhongshan Hospital, Fudan University, 200032 Shanghai, China
*Correspondence: (Lai Wei); (Jinmiao Chen)
These authors contributed equally.
Rev. Cardiovasc. Med. 2023, 24(12), 340;
Submitted: 27 June 2023 | Revised: 4 September 2023 | Accepted: 12 September 2023 | Published: 30 November 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening cardiovascular disorder lacking effective clinical pharmacological therapies. The underlying molecular mechanisms of TAAD still remain elusive with participation of versatile cell types and components including endothelial cells (ECs), smooth muscle cells (SMCs), fibroblasts, immune cells, and the extracellular matrix (ECM). The main pathological features of TAAD include SMC dysfunction, phenotypic switching, and ECM degradation, which is closely associated with inflammation and immune cell infiltration. Among various types of immune cells, macrophages are a distinct participator in the formation and progression of TAAD. In this review, we first highlight the important role of inflammation and immune cell infiltration in TAAD. Furthermore, we discuss the role of macrophages in TAAD from the aspects of macrophage origination, classification, and functions. On the basis of experimental and clinical studies, we summarize key regulators of macrophages in TAAD. Finally, we review how targeting macrophages can reduce TAAD in murine models. A better understanding of the molecular and cellular mechanisms of TAAD may provide novel insights into preventing and treating the condition.

thoracic aortic aneurysm and dissection
82200526/National Natural Science Foundation of China
23QB1400900/Shanghai Rising-Star Program
SHWRS2023-62/Shanghai “Rising Stars of Medical Talents” Youth Development Program
20YF1405400/Shanghai Sailing Program
20224Y0286/Clinical Research Fund of Shanghai Municipal Health Commission
2020YJZX0106/Shanghai Special Research Project on Aging Population and Maternal and Child Health
Fig. 1.
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