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- Academic Editors
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†These authors contributed equally.
Background: Peripheral artery disease (PAD) elevates the risk of
adverse outcomes. The current work aimed to evaluate the influence of PAD in
acute coronary syndrome (ACS) cases administered percutaneous coronary
intervention (PCI), and to determine whether PAD adds incremental prognostic
value to the global registry of acute coronary events (GRACE) scale.
Methods: To retrospectively analyze a single-center, prospective cohort
trial, we consecutively included ACS cases administered PCI. Individuals with and
without PAD were comparatively examined for clinical outcomes. The primary
endpoint was major adverse cardiovascular events (MACEs), a compound item
encompassing all-cause death, myocardial infarction (MI), stroke and repeat
revascularization. The added value of PAD based on a reference model was
examined. Results: PAD was detected in 179 (10.4%) of the 1,770
included patients. The incidence rates of MACEs (40.3% vs. 17.9%), all-cause
death (11.2% vs. 1.6%), cardiovascular death (8.9% vs. 1.4%), MI (8.4% vs.
2.2%) and repeat revascularization (30.2% vs. 15.2%) were all markedly
elevated in PAD cases in comparison with the non-PAD group (p