IMR Press / RCM / Volume 24 / Issue 11 / DOI: 10.31083/j.rcm2411306
Open Access Review
Advancements in the Regulation of Different-Intensity Exercise Interventions on Arterial Endothelial Function
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1 School of Rehabilitation Medicine, Weifang Medical University, 261053 Weifang, Shandong, China
2 School of Health and Life Sciences, University of Health and Rehabilitation Sciences, 266071 Qingdao, Shandong, China
3 School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, 116024 Dalian, Liaoning, China
4 Department of Neurology, Nanjing Drum Tower Hospital Group Suqian Hospital, 223800 Suqian, Jiangsu, China
5 School of Basic Medicine Sciences, Weifang Medical University, 261053 Weifang, Shandong, China
*Correspondence: (Min Cheng); (Yan-Xia Wang)
Rev. Cardiovasc. Med. 2023, 24(11), 306;
Submitted: 16 August 2023 | Revised: 9 September 2023 | Accepted: 12 September 2023 | Published: 1 November 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Normal-functioning endothelium is crucial to maintaining vascular homeostasis and inhibiting the development and progression of cardiovascular diseases such as atherosclerosis. Exercise training has been proven effective in regulating arterial endothelial function, and the effect of this regulation is closely related to exercise intensity and the status of arterial endothelial function. With this review, we investigated the effects of the exercise of different intensity on the function of arterial endothelium and the underlying molecular biological mechanisms. Existing studies indicate that low-intensity exercise improves arterial endothelial function in individuals who manifest endothelial dysfunction relative to those with normal endothelial function. Most moderate-intensity exercise promotes endothelial function in individuals with both normal and impaired arterial endothelial function. Continuous high-intensity exercise can lead to impaired endothelial function, and high-intensity interval exercise can enhance both normal and impaired endothelial function. In addition, it was demonstrated that the production of vasomotor factors, oxidative stress, and inflammatory response is involved in the regulation of arterial endothelial function under different-intensity exercise interventions. We posit that this synthesis will then provide a theoretical basis for choosing the appropriate exercise intensity and optimize the prescription of clinical exercise for persons with normal and impaired endothelium.

arterial endothelial function
cardiovascular diseases
vascular diastolic-systolic factors
oxidative stress
inflammatory reaction
32000927/National Natural Science Foundation of China
31971243/National Natural Science Foundation of China
ZR2020QC092/Shandong Province Natural Science Foundation
Domestic visiting program of Weifang Medical University
Fig. 1.
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