†These authors contributed equally.
Academic Editors: Brian Tomlinson and Takatoshi Kasai
Background and Aims: The incidence of diabetes mellitus has reached an
alarming level. Cardiovascular disease (CVD) is the leading cause of mortality in
diabetic patients. However, the association between ratio and survival outcomes
in patients with diabetes mellitus (DM) and new-onset acute coronary syndrome
(ACS) remains unknown. This study aimed to assess the association between the
TG/HDLC ratio and the risk of death in diabetic patients with new-onset acute
coronary syndrome in the Han Chinese population. Methods: Data in this
study were retrospectively collected from January 2016 to December 2016 from
patients with type 2 diabetes mellitus (T2DM) and new-onset ACS in Tianjin Chest
Hospital. Patients were classified according to the baseline TG/HDLC ratio.
Kaplan-Meier survival curves were used to demonstrate survival
outcomes. Univariate and multivariate Cox proportional risk regression analyses
were used to evaluate the hazard ratios and 95% confidence intervals (CIs) for
the risk of death. Subgroup analysis was used to determine the presence of any
interaction. Results: In total, 152 patients died, 98 of them from heart
disease. The Kaplan-Meier survival curve showed that there were no significant
differences for both all-cause and cardiac mortality between Median 1 and Median
2 in log-rank test. Multivariate Cox regression analyses revealed that the
adjusted hazard ratio increased significantly (p