Dear Colleagues,

Recent advances in the study of regulatory T cells (Tregs) highlight their essential role in maintaining the immune system's homeostasis and treating autoimmune diseases, transplantation rejection, cancers, and microbial infections. Tregs can be found in CD4+ and CD8+ T cell populations. While Treg's clinical trials are ongoing, there are still many challenges in their clinical application. Therefore, continued research is necessary to understand better their mechanisms of action and potential for clinical translation. Accordingly, this special issue will focus on all aspects related to Tregs. I hope that this platform will provide an opportunity for scientists to contribute their new findings and innovative concepts, which will eventually improve the application of Tregs in treating diseases in humans and animals. Both original articles and reviews are welcome. Examples of covered topics include but are not limited to:  

•    CD4+ Tregs.
•    CD8+ Treg. 
•    Genetically engineered Tregs, such as CAR Tregs.

I encourage you to send me an abstract as soon as possible, especially for those who want to contribute a review. The manuscripts will be reviewed when they are received. If accepted, they will be published immediately and appear on the homepage of this special issue.

Dr. Xiaolei Tang

Guest Editor