Background: Acute kidney injury (AKI) is a leading cause of early
post-transplant kidney damage. Furthermore, acute tubular necrosis (ATN) is
appointed as the most prevalent form of AKI, a frequent multifactorial process
associated with high morbidity and mortality, yet giving rise to delayed graft
function (DGF) and, ultimately, allograft dysfunction. Common factors such as
prolonged cold ischemia time, advanced donor age, cadaveric versus living donor,
donor history of hypertension, as well as donation after cardiac death have all
been deemed risk factors for ATN. With the increasing number of older cadaveric
and cardiac donors in the donation process, ATN could have a detrimental impact
on patient welfare. Therefore understanding the underlying process would benefit
the transplant outcome. We aimed to prospectively monitor several T cell subsets
in a cohort of kidney transplant recipients (KTrs) to investigate whether there
is an adaptive immune-mediated involvement in the ATN process. Methods:
Peripheral blood was collected from 31 KTrs at different time points within the
first-year post-transplantation for in vitro stimulation with
Concanavalin-A (Con-A) in a humidified 5% CO
Announcements
Open Access
Original Research
Higher Expression of Activated CD8+ T Lymphocytes (CD8+CD25+, CD8+CD69+ and CD8+CD95+) Mediate Early Post-Transplant Acute Tubular Injury in Kidney Recipients
Francisco Boix1,*, Víctor Jimenez-Coll1, Isabel Legaz2, Rafael Alfaro1, Maria R. Moya-Quiles1, Jesús de la Peña-Moral3, Alfredo Minguela1, Santiago Llorente4, Manuel Muro1
Show Less
1
Immunology Service, Biomedical Research Institute of Murcia (IMIB), Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), 30120 Murcia, Spain
2
Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence “Campus Mare Nostrum'', Faculty of Medicine, University of Murcia, 30120 Murcia, Spain
3
Pathology Service, Biomedical Research Institute of Murcia (IMIB), University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain
4
Nephrology Service, Biomedical Research Institute of Murcia (IMIB), University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain
*Correspondence: franboix82@hotmail.com (Francisco Boix)
Front. Biosci. (Landmark Ed) 2023, 28(6), 119;
https://doi.org/10.31083/j.fbl2806119
Submitted: 8 January 2023 | Revised: 6 May 2023 | Accepted: 31 May 2023 | Published: 27 June 2023
(This article belongs to the Special Issue Regulatory T Cells)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
acute tubular necrosis
immune-mediated damage
CD8+ T lymphocytes
biomarker
kidney transplantation
Funding
P19/01194/“Instituto de Salud Carlos III” (ISCIII), Spanish Ministry of Economy and Competitiveness
European Regional Development Fund (ERDF)
Figures
Fig. 1.