Dear Colleagues,

Autophagy is an important mechanism of cellular degradation which act as a protective mechanism at cellular level under stress conditions such as deprivation of nutrients, growth factors and cellular damage. In addition to its role in normal physiology, autophagy also plays a critical role in cancer cells. Currently, the role of autophagy and metabolism has been explored in the area of cancer progression. One of the emerging theme in autophagy and cancer is how autophagy is important to support tumor growth by activating metabolic phenotypes in the cancer cells. Also, autophagy is known to be a major cause of chemotherapeutic resistance in various cancer cell lines. Therefore, inhibiting autophagy as a therapeutic approach is actively being tested in clinical trials. Also, the various metabolic pathways linked with autophagy could also be a major target for chemotherapeutic strategy. Therefore, understanding how autophagy can fuel cellular metabolism will enable more effective combinatorial therapeutic strategies. This Thematic issue will allow researchers and clinicians to share their research outcome and ideas on a single platform to solve the big problems associated with autophagy and metabolism in cancer.

Prof. Kavindra Kumar Kesari and Dr. Dhruv Kumar

Guest Editors