Dear Colleagues,
Preeclampsia is, a complex and multifactorial disorder unique to pregnancy. It, remains represents a significant global health concern due to its association with adverse maternal and fetal outcomes. Preeclampsia is characterized by hypertension and end-organ damage. It, preeclampsia affects approximately 2–8% of pregnancies worldwide, contributing to maternal morbidity and mortality, as well as adverse neonatal outcomes. Early identification of women at risk of this condition is paramount for timely intervention and improved outcomes.
Recent advances in medical research have underscored highlighted the critical importance of identifying biomarkers and predictive tools for preeclampsia, particularly in the first trimester of pregnancy. Early prediction offers a window of opportunity for preventative strategies, allowing healthcare providers to implement tailored interventions and to closely monitor high-risk pregnancies. The integration of molecular, genetic, and clinical parameters has opened new avenues for refining predictive models and enhancing our understanding of the underlying pathophysiology.
Historically, efforts to predict preeclampsia have primarily focused mainly on maternal characteristics, medical history, and clinical observations. However, emerging evidence suggests that a more comprehensive approach that, incorporating incorporates both clinical and molecular factors, holds promise formay improve enhancing predictive accuracy. Recent studies have identified potential biomarkers for the early identification of women at risk, such asincluding angiogenic and antiangiogenic factors, microRNAs, and genetic polymorphisms, that may contribute to the early identification of women at risk.
Furthermore, advancements in imaging techniques, including such as uterine artery Doppler ultrasound and three-dimensional power Doppler, have provided valuable insights into placental perfusion and vascularization during the first trimester. These non-invasive tools have demonstrated potential in for refining the risk stratification models, contributing to used in the early identification of women at increased risk of preeclampsia.
In conclusion, the pursuit of early prediction and intervention in preeclampsia represents is a dynamic area of research with the potential to revolutionize prenatal care. Ultimately, a deeper understanding of the predictive landscape during the first trimester may pave the way for targeted interventions, thereby improving outcomes for both mothers and infants.
Dr. Hakan Nazik
Guest Editor
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