- Academic Editor
-
-
-
†These authors contributed equally.
Background: To evaluate the effect of carbohydrate antigen 125 (CA125)
and CA19-9 in distinguishing stage Ⅲ and Ⅳ endometriosis from benign and
malignant tumors, and to explore whether it is related to the clinical features
of the disease. Methods: In a retrospective cohort study based on
clinical data from hospitals, a total of 183 patients with pathologically
confirmed diagnosis of ovarian endometriotic cysts (OEC) in Hainan Provincial
People’s Hospital for surgical treatment from January 2019 to August 2022 were
selected as the case group, and a total of 276 cases of benign diseases,
including 184 cases of benign ovarian tumors, 94 cases of gynecological common
diseases, and 102 cases of malignant ovarian tumors were selected as the control
group, with a total of 276 cases of benign diseases, including 184 cases of
benign ovarian tumors, 94 cases of gynecological common diseases, and 102 cases
of malignant ovarian tumors. There were also 23 cases of ruptured ectopic cysts.
We compared the clinical characteristics (age of onset, fertility, dysmenorrhea,
preoperative CA125 and CA19-9 values) of the patients in the OEC group with those
of the other control groups; analyzed the serum CA125 and CA19-9 values in
relation to the pathological characteristics of OEC (recurrence, unilateral and
bilaterality, multilocularity and unilocularity, rupture, dysmenorrhea,
fertility, and staging); and analyzed the CA125 and CA19-9 values by unordered
logistic regression, CA19-9 to predict OEC; sensitivity, specificity and cut-off
values of CA125, CA19-9 and their combined indexes to diagnose OEC.
Results: The symptoms of dysmenorrhea and infertility in OEC group were
significantly higher than those in the other three groups. The preoperative CA125
value in OEC group was higher than that in benign tumor and other gynecological
diseases group, and significantly lower than that in malignant tumor group. There
was no significant difference in the value of CA19-9 and CA125 in the degree of
dysmenorrhea, recurrence and infertility. The values of CA19-9 and CA125 of
multilocular cysts were higher than those of unicameral cysts, bilateral cysts
were higher than unilateral cysts, and ruptured cysts were significantly higher
than unruptured cysts. The value of CA125 in the dysmenorrhea group was higher
than that in the non-dysmenorrhea group, and that in the fourth stage was higher
than that in the third stage, and the difference was statistically significant
(p