IMR Press / CEOG / Volume 51 / Issue 1 / DOI: 10.31083/j.ceog5101004
Open Access Original Research
Decreased Expression of Cav-1 Is Associated with Compromised Endometrial Angiogenesis during the Implantation Window in PCOS Rats: A Prospective Randomized Laboratory-Based Study
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1 Department of Traditional Chinese Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 200080 Shanghai, China
2 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, 200120 Shanghai, China
*Correspondence: (Guozeng Wang)
Clin. Exp. Obstet. Gynecol. 2024, 51(1), 4;
Submitted: 25 May 2023 | Revised: 15 August 2023 | Accepted: 22 August 2023 | Published: 8 January 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Caveolin-1 (Cav-1) is known to regulate angiogenesis. However, little is known about Cav-1’s role in polycystic ovary syndrome (PCOS). This study aims to investigate Cav-1’s expression in the endometrium of PCOS rats during the implantation window and its association with endometrial angiogenesis. Methods: Female Sprague Dawley (SD) rats were randomly divided into the control and PCOS groups. The rats in the PCOS group mated after ovulation induction, while the rats in the control group mated during the estrus period. On the 2nd and 5th days of pregnancy, the rats were sacrificed, and the endometrium was isolated from their uteruses. Immunohistochemistry (IHC) staining of CD34 was used to evaluate the endometrial micro-vessel density (MVD). The expression of Cav-1 and vascular endothelial growth factor (VEGF) in the endometrium of both groups was assessed through IHC staining and real-time reverse transcription polymerase chain reaction (RT-PCR) analysis. Results: IHC analysis of endometrium tissue sections showed reduced MVD in PCOS rats on both the 2nd and 5th days of pregnancy. The endometrial expression of Cav-1 and VEGF were also significantly downregulated in the PCOS group compared to the control group during the implantation window. Interestingly, the endometrial expression of Cav-1 was positively correlated with MVD and VEGF. Conclusions: Our study demonstrated the decreased endometrial angiogenesis in PCOS rats during implantation window. This decrease was linked to decreased Cav-1 expression, suggesting Cav-1 is a potential therapeutic target for PCOS patients.

endometrial angiogenesis
endometrial receptivity
polycystic ovarian syndrome
2016LP024/Special Project of Traditional Chinese Medicine Scientific Research of Shanghai Health and Family Planning Commission
ZY( 2018-2020)-RCPY-3006/“Xinglin Xinxing” Talent Project of Shanghai
Fig. 1.
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