- Academic Editor
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Background: Sickle cell disease (SCD) is one of the most prevalent
genetic disorders, including major SCD and SC Trait (SCT) genotypes.
Many studies have shown a negative association between major SCD and pregnancy.
However, they are underestimated in Cote d’Ivoire statistics. To provide
consistent data on SCD in pregnancy, we compare outcomes between women with
normal hemoglobin (Hb) genotype and major SCD. Methods: A
retrospective, and case-control study in the University Hospital of Cocody, from
2015 to 2018, analyzed maternal and fetal outcomes, comparing the Cases Group:
major SCD (HbSS, HbSC) and Control Group: normal hemoglobin (Hb) genotype A. Only
pregnancies with gestations longer than 28 weeks were included. No cases of
thalassemia or variant of hemoglobin were found. Local protocols recommended
systematic use of vasodilators or analgesics, folic acid, and high concentrations
of inhaled oxygen during labor, associated with fluid and/or blood transfusion.
We excluded sickle cell trait (SCT) genotype AS (HbAS), and incomplete
data. A logistic regression was exploited to gauge the risk factors. We used SPSS
version 19 (IBM Corp., Armonk, NY, USA) for statistical analysis, and calculate
the adjusted odds ratio and 95% confidence interval. Results: We
registered 156 major SCD (0.92%), compared to 312 HbAA. In Cases Group
27.6% were multigravidas (