Background: This study aims to investigate the clinical features, diagnosis and treatment of deep vein thrombosis in early pregnancy. Methods: The clinical manifestations, diagnosis, treatment and prognosis of 6 pregnant women with deep vein thrombosis in early pregnancy who were hospitalized in Hubei Maternal and Child Health Hospital from July 2020 to July 2022 were analyzed retrospectively. Results: One patient underwent inferior vena cava angiography + inferior vena cava filter placement + indwelling catheter thrombolysis + lower extremity venous balloon dilatation followed by uterine curettage to terminate the pregnancy, and 3 patients underwent uterine curettage after low molecular weight heparin therapy. Thrombosis was alleviated in the remaining 2 patients who were still continuing the pregnancy. Conclusions: Lower extremity venous thrombosis in early pregnancy was not an indication for termination of pregnancy. A good clinical prognosis can still be obtained after early detection, diagnosis, and treatment.