IMR Press / CEOG / Volume 50 / Issue 5 / DOI: 10.31083/j.ceog5005103
Open Access Original Research
Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women
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1 Department of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, China
*Correspondence: (Wei Xia)
These authors contributed equally.
Clin. Exp. Obstet. Gynecol. 2023, 50(5), 103;
Submitted: 11 October 2022 | Revised: 21 December 2022 | Accepted: 27 December 2022 | Published: 16 May 2023
(This article belongs to the Special Issue Assisted Reproductive Technologies)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Overweight affects about 34.3% of Chinese adults, especially women of childbearing age. The purpose of this study was to investigate whether overweight affect the live birth rate of frozen-thawed embryo transfer (FET) cycles in Chinese mothers. Methods: This retrospective case-control study was conducted in all patients undergoing FET cycles from May 2016 to October 2020 at a single center. A total of 969 FET cycles performed in 632 patients were included in the analysis. Patients were divided into the four groups based on the mother’s body mass index (BMI): Group 1: BMI <18.5 kg/m2; Group 2: 18.5 kg/m2 BMI <24 kg/m2; Group 3: 24 kg/m2 BMI <28 kg/m2; Group 4: BMI 28 kg/m2. The main outcome indicator was the live birth rate per FET cycle. The secondary endpoints included rates of biochemical clinical pregnancy, clinical pregnancy, implantation, multiple pregnancy and miscarriage. Results: Ovarian reserve parameters were similar among the four groups (p = 0.382 for anti-Müllerian hormone and p = 0.195 for antral follicle count). Additionally, the rates of chemical pregnancy, clinical pregnancy, implantation and live birth were comparable in the four groups. Pregnancy outcomes were similar among the four groups using logistic regression analysis adjusting for age, anti-Müllerian hormone (AMH), antral follicle count (AFC), endometrial thickness, indication combined with polycystic ovarian syndrome (PCOS), duration of infertility (years), stage of embryos transferred, previous attempts, protocol of endometrial preparation, number of embryos transferred, and BMI. A decreasing tendency in the rates of clinical pregnancy (p = 0.032) and live birth (p = 0.011) with BMI change was observed through Chi Square for Trend test. Conclusions: Overweight might reduce the possibility of live birth after FET cycles in Chinese mothers.

live birth rate
frozen-thawed embryo transfer cycle
Q2019001/Science Foundation of Guangzhou First People’s Hospital
20201A011002/Guangzhou Municipal Health Science and Technology General Guidance Project
A2022300/Medical Scientific Research Foundation of Guangdong Province of China
2023C-TS61/Featured Clinical Technique of Guangzhou
Fig. 1.
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