- Academic Editor
Background: To evaluate the effect of distance, professional behaviour
education and guidance on reducing adverse pregnancy outcomes in women with
gestational diabetes mellitus (GDM). Methods: Women with GDM who had
undergone regular prenatal care and gave birth at Jinshan Branch of Shanghai
Sixth People’s Hospital from January 2019 to October 2020 were enrolled. A random
number table method was utilized to divide the patients into a control group (168
cases) and an intervention group (182 cases). In the control group, routine
prenatal education was conducted, while in the intervention group, in addition to
routine prenatal education, providers used video and the WeChat public platform
to regularly impart knowledge and behaviour education to women with GDM and
supervise the implementation of their actions. The pregnancy outcomes of the two
groups were compared. Results: ① Fasting plasma glucose (FPG),
2-hour postprandial blood glucose (2hPG) and glycohemoglobin (HbAlc) in the
intervention group were significantly lower than that of the control group
(p
Gestational diabetes mellitus (GDM) is characterized by abnormal glucose tolerance, which is caused by increased insulin resistance during pregnancy [1]. The incidence of GDM is approximately 5.12%–33.3% in China [2] with an increasing upwards trend. There is evidence that GDM and the resulting maternal hyperglycaemia are associated with adverse perinatal outcomes, and evidence exists that monitoring and treatment of GDM can reduce these adverse outcomes [3]. Women with GDM can experience reproductive tract infections that can cause varying degrees of harm to the quality of life of patient, her infant’s health and increase adverse pregnancy outcomes [4]. WHO suggests that pregnant women perform self-management, control their blood glucose and maintain their vaginal microecological balance, all which can improve pregnancy outcomes. Diet and blood glucose monitoring is the first-line therapy method for women with GDM [5]. However, often medication is more valued by doctors and researchers than lifestyle interventions, and methods using diet and exercise are often ignored. Personalized nutritional intervention therapy for women with GDM significantly reduces their blood glucose levels and improves their pregnancy outcomes [6]. Without professional medical supervision, nearly 90% of women with GDM fail to adopt a successful self-administered diet and exercise program [7]. Carolan Olah’s study [8] demonstrated that the use of interventions including low glycaemic index diet and increased activity levels can successfully reduce the blood glucose level of pregnant women and reduce insulin demand during pregnancy, thereby reducing maternal weight gain and associated macrosomia. Impacted by a lack of patient compliance, follow-up conditions and living in remote areas, face-to-face communication between doctors and patients is limited. Adesina et al. [9] have shown that using digital tools is likely to be an effective method to support GDM patients’ self-management in healthy diet, healthy behaviour and adherence to treatment. Therefore, we remotely guided pregnant women to manage their diet, exercise, blood glucose and vaginal microecological environment through the form of a WeChat group, which has achieved supportive data in improving pregnancy outcomes.
Participants included women with GDM who had undergone regular prenatal care and
gave birth at the Jinshan Branch of Shanghai Sixth People’s Hospital from January
2019 to October 2020. A random number table method was used to divide the
patients into a control group and an intervention group. Inclusion criteria: (1)
women with GDM and age
Flow chart of subject recruitment for personalized education and supervision clinical research of women with gestational diabetes mellitus.
Diagnosis of GDM: oral glucose tolerance test (OGTT) at 24 to 28 weeks of gestation, fasting, 1 hour and 2 hours blood glucose levels that meets or exceeds 5.1 mmol/L, 10.0 mmol/L or 8.5 mmol/L, respectively [4].
The research team consisted of 2 obstetricians, and one of them is the chief physician of gestational diabetes, 2 dietitians, 1 psychological consultant and 8 nursing staff. The established research team developed a unified process, and conducted training prior to the intervention. The team consisted of 2 obstetricians who performed regular antenatal examinations, assessed the risks of GDM, and conducted nutrition and exercise health education; 2 dietitians who designed the diet plan; 1 psychological consultant for counselling; and 8 clinical nursing staff responsible for the online knowledge and WeChat group supervision of the women according to the diet and exercise plan implemented and being available to answer questions, engage in data collection and conduct follow-up.
Control group: A routine hospital obstetric examination mode was adopted. Routine health care guidance was provided for women with GDM during each antenatal visit. Printed materials were distributed to provide health education and guidance on GDM knowledge, nutrition during pregnancy, exercise, vaginal microecology, the childbirth process, neonatal nursing methods, breastfeeding and an understanding of the postpartum period.
Intervention group: In addition to the practices for the control group, professionals on the research team conducted online guidance and supervision of new media, publicized education and behaviour supervision by using the WeChat group and the “Obstetrics and Gynaecology” public account. WeChat group is a platform for individuals to chat and exchange. It can send voice messages, videos, pictures and text through a mobile phone network. Compared with traditional office methods, a WeChat work group has the advantages of being paperless, convenient, interactive and timely.
(1) Knowledge: ① GDM and vaginal microecology knowledge education:
teaching pregnant women about GDM vaginal microecology knowledge, adverse effects
on maternal and infant outcomes, and issues requiring attention during pregnancy
were explained to the women by means of school lectures, videos and the WeChat
public platform. ② Dietary education: the pregnant women were guided to
keep food diaries, engage in self-monitoring of blood glucose four times a day
(fasting blood glucose and blood glucose 2 hours after each meal), and according
to the blood glucose monitoring results, the blood glucose was monitored for 2 or
3 days a week. They were asked to record their weight each day. The pregnant
women were asked to check in with the WeChat group daily. The dietitians adjusted
their dietary intake according to their blood glucose level and weight, developed
personalized dietary programs to ensure an adequate supply of calories and
nutrients during pregnancy and to avoid the occurrence of postprandial
hyperglycaemia and starvation ketosis. The diet plan involved obtaining 45–50%
of calories from carbohydrates, 20–25% from protein, and 30% from fats. The
blood glucose control target range was fasting 3.6–5.3 mmol/L and 2 hours after
a meal
(2) Behaviour: the pregnant women could contact the nursing staff through WeChat to answer any questions and to regularly monitor and evaluate the GDM women’s progress according to their medical behaviour and self-management ability. The team could provide the corresponding nursing care according to the maternal situation and provide regular telephone follow-ups or on-site visits to investigate and evaluate the maternal education content, supervise or strengthen their self-management, health, science and rational behaviour based on the importance of disease prevention and control in accordance with the doctor’s advice.
The two groups of patients were evaluated before delivery by the Summary of
Diabetes Self Care Activities (SDSCA) [10] for the six dimensions of general
diet, special diet, exercise, blood glucose monitoring, foot care, and medicine
use. The total score of each dimension was the total score of the scale. The
lowest score was 0 and the highest was 77. The score was positively correlated
with good self-management behaviour. The SDSCA score of the study group (55.68
In the third trimester (28 weeks to delivery) in both groups, vaginal secretions
were collected from the posterior fornix with sterile cotton swabs. Dry chemical
examination indices of the vaginal secretions (Production Lot No. 20208110,
Zhuhai Lizhu Reagent Company Limited, Zhuhai, Guangdong, China) included the
following: pH, hydrogen peroxide (H
Alternate types of vaginitis refer to infections with Neisseria gonorrhoeae, Ureaplasma urealyticum (UU) and Chlamydia trachomatis (CT). Cervical secretions were collected to detect the DNA of Neisseria gonorrhoeae (Production Lot No. 20200320, Shanghai Comaga Microbial Technology Ltd, Shanghai China), UU (Production Lot No. 20200510, Zhengzhou Antu Biological Engineering Ltd, Zhengzhou, Henan, China) and CT (Production Lot No. 20200430, Abbott Biopharmaceuticals Ltd, Suzhou, Jiangsu, China) by PCR [11]. Cleanliness inspection of vaginal secretion: Cleanliness III is less vaginal bacilli, more mixed bacteria and white blood cells; There were no vaginal bacilli in Cleanliness IV, all of which were mixed bacteria and more white blood cells. Cleanliness III/IV indicates that the vaginal flora is dysregulated, which is of great significance for the diagnosis of vaginitis.
Sexual activity, vaginal medication and irrigation were prohibited within 48 hours before sample collection.
(1) One month before delivery in both groups: fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), and glycohemoglobin (HbAlc);
(2) In the third trimester (28 weeks to delivery) in both groups: thyroid peroxidase antibody (TPOAb), free thyroxine (FT4), and thyroid-stimulating hormone (TSH);
(3) In the third trimester (28 weeks to delivery) in both groups: vaginal
secretion pH, hydrogen peroxide (H
(4) The women in both groups had any adverse pregnancy outcomes recorded with, the primary observation indicators being: excessive weight gain during pregnancy, preeclampsia (PE), polyhydramnios, preterm premature rupture of membranes (PPROM), premature rupture of membranes (PROM), puerperal infection, foetal growth restriction (FGR) and chorioamnionitis; the secondary observation indicators being: caesarean section, puerperal infection, amniotic fluid pollution, oligohydramnios, placenta previa, placental abruption, foetal distress and postpartum haemorrhage (PPH);
(5) Neonatal adverse outcomes in the 2 groups were recorded with the primary observation indicators being: macrosomia, large for gestational age (LGA), neonatal pneumonia, preterm infant, neonatal hypoglycaemia and neonatal abnormality; the secondary observation indicators being: neonatal care, neonatal Apgar score less than 7 at a minute, neonatal death, small for gestational age (SGA) and hyperbilirubinemia.
The data were analysed by SPSS 26.0 (IBM Corp., Chicago, IL, USA). The Shapiro
Wilk method was used to test for normal distribution. Quantitative data that
conformed to the normal distribution were expressed as mean
The fasting and 2-hour postprandial blood glucose of the intervention group were
within the normal range, while the fasting and 2-hour postprandial blood glucose
of the control group were higher than the normal range, and the difference
between the two groups was statistically significant (p
Group | Cases (n) | FPG (mmol/L) | 2hPG (mmol/L) | HbAlc (%) |
---|---|---|---|---|
Intervention group | 182 | 4.83 |
6.31 |
5. 26 |
Control group | 168 | 5.61 |
7.12 |
6. 26 |
T | / | 15.1164 | 11.9964 | 16.6182 |
p | / |
The positive rate of TPOAb in the study group was lower than that in the control
group, and the level of FT4 in the intervention group was higher than that in the
control group, but neither reached significant difference (p
Group | Cases (n) | TPOAb positive (n, %) | FT4 (pmol/L) | TSH (mIU/L) |
---|---|---|---|---|
Intervention group | 182 | 10(5.49) | 17.59 |
2.65 |
Control group | 168 | 11(6.55) | 17.28 |
3.57 |
T/ |
/ | 0.172 | 1.653 | 14.578 |
p | / | 0.679 | 0.099 |
The incidences of BV, VVC, UU, GBS, cleanliness III/IV and the positive
incidences of hydrogen peroxide, neuraminidase and leukocyte esterase in the
intervention group were significantly lower than those of the control group
(p
Group | Cases | Vaginal pH | Vaginal BV (+) | VVC | TV | GBS (+) | Cleanliness III | Cleanliness IV |
---|---|---|---|---|---|---|---|---|
Intervention group | 182 | 4.11 |
7 (3.85) | 16 (8.79) | 2 (1.10) | 13 (7.14) | 24 (13.19) | 15 (8.24) |
Control group | 168 | 3.79 |
16 (9.52) | 33 (19.64) | 3 (1.79) | 23 (13.69) | 43 (25.60) | 30 (17.86) |
T/ |
/ | 20.362 | 4.587 | 8.544 | 0.293 | 4.059 | 8.690 | 7.209 |
p | / | 0.032 | 0.003 | 0.589 | 0.044 | 0.003 | 0.007 |
Group | Leucocyte esterase | Neuraminidase | Hydrogen peroxide | NAG | PA | UU | CT | Neisseria gonorrhoeae |
---|---|---|---|---|---|---|---|---|
Intervention group | 107 (58.79) | 55 (30.22) | 130 (71.43) | 19 (10.44) | 8 (4.40) | 34 (18.68) | 2 (1.10) | 1 (0.55) |
Control group | 133 (79.17) | 78 (46.43) | 139 (82.74) | 28 (16.67) | 13 (7.74) | 63 (37.50) | 4 (2.38) | 2 (1.19) |
T/ |
16.829 | 9.742 | 6.282 | 2.914 | 1.731 | 15.443 | 0.852 | 0.422 |
p | 0.002 | 0.012 | 0.088 | 0.188 | 0.356 | 0.516 |
Comparison of vaginal microorganisms in the third trimester
(p
Preeclampsia, polyhydramnios, preterm premature rupture of membranes, premature
rupture of membranes, puerperal infection, amniotic fluid pollution,
chorioamnionitis and caesarean section in the intervention group were
significantly lower than those in the control group (p
Group | Cases (n) | Weight gain during pregnancy (kg) | Foetal distress | Preeclampsia | FGR | Oligohydramnios | Puerperal infection | Polyhydramnios |
---|---|---|---|---|---|---|---|---|
Intervention group | 182 | 13.89 |
7 (3.85) | 12 (6.59) | 3 (1.65) | 7 (3.85) | 24 (13.19) | 10 (5.49) |
Control group | 168 | 16.37 |
11 (6.55) | 22 (13.10) | 4 (2.39) | 10 (5.95) | 43 (25.60) | 19 (11.31) |
T/ |
/ | 6.4852 | 1.307 | 4.211 | 0.239 | 0.839 | 8.690 | 3.887 |
p | / | 0.000 | 0.253 | 0.040 | 0.625 | 0.360 | 0.003 | 0.049 |
RR | / | / | 0.503 | / | / | 0.515 | 0.486 |
Group | Postpartum haemorrhage | Placenta previa | Premature rupture of membranes | Preterm premature rupture of membranes | Placental abruption | Amniotic fluid pollution | Chorioamnionitis | Caesarean section |
---|---|---|---|---|---|---|---|---|
Intervention group | 11 (6.04) | 5 (2.75) | 14 (7.70) | 6 (3.30) | 1 (0.55) | 9 (4.95) | 40 (21.98) | 57 (31.32) |
Control group | 15 (8.93) | 6 (3.57) | 25 (14.88) | 14 (8.33) | 2 (1.19) | 22 (13.10) | 58 (34.52) | 71 (42.26) |
T/ |
1.057 | 0.195 | 4.560 | 4.113 | 0.422 | 7.188 | 6.821 | 4.510 |
p | 0.304 | 0.659 | 0.033 | 0.043 | 0.516 | 0.007 | 0.009 | 0.034 |
RR | / | / | 0.517 | 0.396 | / | 0.378 | 0.637 | 0.741 |
The comparisons of the adverse outcomes between the groups
(p
The incidence of macrosomia, gestational age, neonatal care, neonatal
hypoglycaemia and neonatal pneumonia in the intervention group was significantly
lower than that in the control group (p
Group | Cases (n) | Preterm infant | Foetal macrosomia | Small for gestational age infants | 1 minute Apgar |
Neonatal care |
---|---|---|---|---|---|---|
Intervention group | 182 | 10 (5.49) | 19 (10.44) | 4 (2.20) | 3 (1.65) | 10 (5.49) |
Control group | 168 | 16 (9.52) | 37 (22.02) | 4 (2.38) | 6 (3.57) | 23 (13.69) |
T/ |
/ | 2.062 | 8.723 | 0.526 | 1.290 | 6.872 |
p | / | 0.151 | 0.003 | 0.468 | 0.256 | 0.009 |
RR | / | / | 0.485 | / | / | 0.401 |
Group | Hyperbilirubinemia | Hypoglycaemia | Neonatal defects | Large for gestational age infants | Neonatal death | Neonatal pneumonia |
---|---|---|---|---|---|---|
Intervention group | 21 (11.54) | 15 (8.24) | 3 (1.65) | 13 (7.14) | 1 (0.55) | 9 (4.95) |
Control group | 23 (13.69) | 35 (20.83) | 5 (2.97) | 31 (18.45) | 1 (0.60) | 22 (13.10) |
T/ |
0.368 | 10.761 | 0.690 | 10.166 | 0.003 | 7.188 |
p | 0.544 | 0.001 | 0.406 | 0.001 | 0.955 | 0.007 |
RR | / | 0.936 | / | 0.387 | / | 0.378 |
The comparison of the incidence of adverse neonatal outcomes
(p
GDM is one of the common complications of pregnancy. Improper control of blood glucose levels can have a negative impact on maternal and infant outcomes. The 2008 “Study on hyperglycaemia and adverse pregnancy outcomes (HAPO)” found that GDM not only increased the risk of perinatal adverse outcomes such as macrosomia, respiratory distress, neonatal hypoglycaemia and shoulder dystocia [12] but also increased the risk of maternal and neonatal long-term metabolic disorders [13]. Therefore, it is necessary to pay attention to pregnant women with GDM. Diet, exercise and self-monitoring of blood glucose are preferred as first-line treatment. Patients should be encouraged to be on a standard diet and engage in exercise, blood glucose monitoring and strict glycaemic control in order to improve pregnancy outcome [14]. According to this report, using a social software platform, instant messaging, and utilization of telemedicine in women with GDM may improve patients’ compliance and outcomes [15].
Our study investigated the clinical significance of dietary and exercise interventions, microecological protection, obesity control and other health education tools in order to improve maternal and infant outcomes in women with GDM. The results of the study found that the fasting and 2-hour postprandial blood glucose in the intervention group were within the normal range one month before delivery, while the fasting and 2-hour postprandial blood glucose in the control group were higher than the normal range. The mean value of glycosylated haemoglobin in the two groups was normal, but in the intervention group was significantly lower than in the control group. Koivusalo et al. [16] have shown that diet, exercise and weight management before 20 weeks of gestation can reduce the risk of GDM in high-risk pregnant women by 39%. Miremberg et al. [17] have shown that using mobile device management of GDM in pregnant women can improve the rate of monitoring their compliance and blood glucose, which is consistent with our results. Ming et al.’s [18] study on telemedicine for GDM showed a decrease in HbA1c levels, which is consistent with the results of our study.
In this study, the TPOAb-positive rate was slightly lower and the FT4 level was slightly higher in the intervention group in the third trimester; the TSH level was significantly lower than that of the control group. According to the 2011 ATA guidelines, pregnant women with type 1 diabetes are prone to hypothyroidism [19]. Reports exist that when TSH levels during pregnancy are basically normal, the FT4 content is related to the degree of impaired glucose tolerance. The more impaired the glucose tolerance is, the less insulin is secreted, which will lead to a disorder of glucose metabolism and affect the secretion of thyroxine [20]. This study suggests that personalized educational behaviour management has a positive protective effect on thyroid function in women with GDM.
The female vaginal microbial flora, anatomical structure, endocrine regulation function and immune system constitute the female vaginal microecosystem. The increase in blood glucose and hormone levels in patients with GDM leads to an imbalance of the vaginal microecology and a decrease in the number of vaginal Lactobacillus, which can lead to the colonization of abnormal pathogens and an increase in vaginal infections [21]. The influencing factors on the vaginal microecology of pregnant women include vaginal flushing, sexual behaviour and menstrual cycle [22]. Women with GDM in the intervention group were provided with standard vaginal microecological knowledge and methods of self-protection. Their incidences of BV, VVC, UU, GBS, III/IV and positive incidences of hydrogen peroxide, neuraminidase and leukocyte esterase were significantly lower than those of the control group. The vaginal pH of the intervention group was significantly higher than that of the control group. The incidences of TV, CT, NAG, PA and Neisseria gonorrhoeae were lower than those in the control group, but the difference was not statistically significant. This is consistent with the results of Dunn et al. [23] that good personal protection and early recovery of normal vaginal microecology can eliminate all kinds of pathogenic vaginitis.
When maternal GDM occurs, vaginal microecology and immunosuppression can lead to
a decline in maternal resistance, which may lead to premature rupture of
membranes and other complications [24]. In this study, the incidences of PPROM,
PROM, puerperal infection, amniotic fluid contamination and chorionic amniotic
separation in the intervention group were significantly lower than that in the
control group, and RR
Dall et al. [25] have shown that the occurrence of GDM can have adverse effects on pregnant women and newborns including pregnancy-induced hypertension, polyhydramnios, caesarean section, infection, macrosomia, premature infants, neonatal hypoglycaemia, premature rupture of membranes and other pregnancy complications. In addition, GDM also increases the risk of development of maternal and infant diabetes [26]. The risk of caesarean section is increased along with the risk of foetal macrosomia and shoulder dystocia [27]. In our study, the incidence of pregnancy weight gain, preeclampsia, polyhydramnios and caesarean section in women with GDM in the intervention group was significantly lower than that in the control group. The incidences of oligohydramnios, FGR, placenta previa, placental abruption and postpartum haemorrhage were lower than those in the control group. Implementation of personalized nutrition therapy in patients with GDM can significantly control the consequences of GDM and reduce the incidence of complications related to pregnancy [28]. The results of our study further suggest that standardized knowledge and behaviour education and supervision can improve adverse pregnancy outcomes. Lower weight gain is associated with a lower incidence of preeclampsia in women with GDM [29].
Fang et al. [30] have shown that the teratogenic rate of GDM pregnant
women is 7–10 times higher than that of normal women, but the malformations are
likely due to undiagnosed Type1/2 DM. In our study, the neonatal defects in the
intervention group were higher than those in the control group, but the
difference was not statistically significant, which was consistent with the
literature. Macrosomia has been proven to be the main adverse outcome of GDM
patients [31]. GDM is also a risk factor for birth defects [32]. Kalra et
al. [33] have shown that implementing clinical interventions for women with GDM
can effectively control weight gain during pregnancy and reduce the risk of
caesarean section and macrosomia along with the occurrence of other adverse
pregnancy outcomes. In our study, the incidence of macrosomia, neonatal
monitoring care, neonatal hypoglycaemia and neonatal pneumonia in the
intervention group was significantly lower than that in the control group, and RR
The WeChat group of remote interventions is a new type of health education mode that eliminates the doctor–patient space distance and guides and supervises patients anytime or anywhere. Medical professional knowledge provided through images, animation, or voice educates women with GDM, making them better understand the potential problems and enhance their self-management ability in order to achieve effective control of their blood glucose. Our study indicates that GDM patients treated with repeated dietary advice, monitoring of blood glucose levels and advice on increasing daily activity, such as walking or other exercise improves the function of their thyroid gland and vaginal microecological condition. This approach reduces rates of adverse outcomes, such as infant death or birth damage and reduces macrosomia and maternal weight gain.
Our study sample size was small, and due to the imperfection of the means of intervention, we hope to conduct a future multicentre study discussing the remote online intervention mode of women with GDM and providing valuable data for the health education and clinical care for women with GDM.
The professional health educators in this study promoted health education of women with GDM by setting up a WeChat group and providing answers to their questions. At the same time, the establishment of the WeChat group allowed the women to share their experiences with the group, and it was easier to obtain a follow-up focus on health education.
Based on these research results, the specifications of prenatal care are effective in actively improving the pregnancy outcomes of women with GDM. We demonstrated that remote mobile medical management can assist pregnant women in controlling their diet, engaging in exercise, improving their blood glucose management awareness, promoting self-management habits and reducing the occurrence of maternal and infant adverse events. We hope that this combination of online management methods can be further researched and promoted, improving the efficiency of disease management research, and furthering the discussion of remote interventions for women with GDM via knowledge management modes. The purpose of this study was to explore a standardized knowledge and behaviour management model for women with GDM to provide valuable data for future GDM guidelines and health promotion plans. Health education and clinical practice to improve self-management of women with GDM will be the focus of future research. In this study, we used statistical comparative analysis to confirm that WeChat group is simple and easy to operate. It can communicate at any time through mobile phones. Online intervention includes medical workstation and remote consultation which can realize automatic uploading, classification, analysis and reminder of test data. More professional team telemedicine, which can be closely supervised while utilizing online education and intervention and allows adjustment of personalized programs at any time can effectively improve the pregnancy outcome of patients with gestational diabetes.
The datasets supporting the conclusions of this article are included within the manuscript. The demanders may contact the corresponding author.
YZ finished the conception, design, and implementation of the project, and prepared the manuscript. GG assisted in the conception and design of the project, provided technical assistance. All authors contributed to editorial changes in the manuscript. All authors approved the final manuscript and agreed to be accountable for all aspects of the work.
This study was approved by the Ethics Committee of Jinshan Branch of Shanghai Sixth People’s Hospital (approval number: jszxyy201803). Written informed consent was obtained from the patients for publication of clinical details, clinical images, and videos.
We thank AJE (https://www.aje.com) for its linguistic assistance during the preparation of this manuscript.
This research supported by Jinshan District Medical and Health Science and Technology Innovation Fund Project (No. 2022-WS-06) and research fund for medical consortium construction of Shanghai Sixth People’s Hospital Medical Group (No: 02.2Y02.07.023).
The authors declare no conflict of interest.
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