Background: The severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) virus is continually evolving, and the worldwide
epidemic is still ongoing. There is conflicting evidence regarding how SAS-CoV-2
infection affects the outcomes of assisted reproductive technology (ART). The aim of this study was to investigate whether the outcomes of in
vitro fertilization (IVF) treatment were affected during the acute period of
SARS-CoV-2 infection or immediately after recovery from coronavirus disease 2019
(COVID-19). Methods: In this retrospective cohort study,
SARS-CoV-2-infected couples who underwent IVF treatment at Wuhan Union Hospital
within the first three months following the lifting of the pandemic policy in
mainland China were propensity-score matched (PSM) to uninfected couples who
received IVF during the dynamic COVID-zero policy. Following matching, 358 and
698 patients were assigned to the SARS-CoV-2-infected and uninfected groups,
respectively. The laboratory and clinical outcomes of the two groups were
compared. Results: The blastocyst formation rates were considerably
lower in the infected group than in the uninfected group. Stratification by time
from SARS-CoV-2 infection to oocyte retrieval (
Announcements
Open Access
Original Research
Effect of SARS-CoV-2 Infection on IVF/ICSI-ET Outcomes: A Propensity Score-matched Cohort Study
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1
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China
*Correspondence: 494804802@qq.com (Hui Ding)
Clin. Exp. Obstet. Gynecol. 2023, 50(12), 278;
https://doi.org/10.31083/j.ceog5012278
Submitted: 3 September 2023 | Revised: 5 October 2023 | Accepted: 12 October 2023 | Published: 29 December 2023
(This article belongs to the Special Issue In-Vitro Fertilization (IVF))
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
COVID-19
IVF
SARS-CoV-2
infertility
embryo
pregnancy
Funding
2022CFB243/Hubei Provincial Natural Science Foundation of China
Figures
Fig. 1.