IMR Press / CEOG / Volume 50 / Issue 12 / DOI: 10.31083/j.ceog5012278
Open Access Original Research
Effect of SARS-CoV-2 Infection on IVF/ICSI-ET Outcomes: A Propensity Score-matched Cohort Study
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1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China
*Correspondence: (Hui Ding)
Clin. Exp. Obstet. Gynecol. 2023, 50(12), 278;
Submitted: 3 September 2023 | Revised: 5 October 2023 | Accepted: 12 October 2023 | Published: 29 December 2023
(This article belongs to the Special Issue In-Vitro Fertilization (IVF))
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus is continually evolving, and the worldwide epidemic is still ongoing. There is conflicting evidence regarding how SAS-CoV-2 infection affects the outcomes of assisted reproductive technology (ART). The aim of this study was to investigate whether the outcomes of in vitro fertilization (IVF) treatment were affected during the acute period of SARS-CoV-2 infection or immediately after recovery from coronavirus disease 2019 (COVID-19). Methods: In this retrospective cohort study, SARS-CoV-2-infected couples who underwent IVF treatment at Wuhan Union Hospital within the first three months following the lifting of the pandemic policy in mainland China were propensity-score matched (PSM) to uninfected couples who received IVF during the dynamic COVID-zero policy. Following matching, 358 and 698 patients were assigned to the SARS-CoV-2-infected and uninfected groups, respectively. The laboratory and clinical outcomes of the two groups were compared. Results: The blastocyst formation rates were considerably lower in the infected group than in the uninfected group. Stratification by time from SARS-CoV-2 infection to oocyte retrieval (30, 31~60, 61~90 and 90 days) revealed that both blastocyst formation and available blastocyst rates were significantly decreased when oocyte retrieval was performed 31~60 days after SARS-CoV-2 infection. However, after the first embryo transfer cycle, there were no significant differences in the rates of embryo implantation, biochemical pregnancy, clinical pregnancy or early abortion between the two matched cohorts. Conclusions: SARS-CoV-2 infection had no effect on clinical outcomes after the first embryo transfer cycle; however, the rate of blastocyst formation was considerably lower in couples who received IVF treatment 31~60 days after SARS-CoV-2 infection, indicating that SARS-CoV-2 infection may continue to impair embryo developmental potential.

2022CFB243/Hubei Provincial Natural Science Foundation of China
Fig. 1.
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