Background: Non-alcoholic fatty liver disease (NAFLD) has long been
considered to be most prevalent chronic hepatic disease. However, the overall
prevalence of NAFLD in postmenopausal women was largely unknown.
Objectives: In the current study, we aimed to investigate the overall
prevalence of NAFLD in postmenopausal women in order to provide more information
for clinical work. Methods: A systematic search was conducted in
Medline, Embase, web of science and Cochrane for articles in the English language
from inception until May 2020. Wilson score method was used to calculate the 95%
confidence interval (95% CI) and DerSimonian-Laird random-effects model with
Freeman-Tukey double arcsine transformation was used for estimating pooled
overall prevalence. Results: Our search returned 4465 records. After
removed duplicates and screened titles, abstract and full content of articles, 25
studies were retrieved. Overall, the NAFLD prevalence was 30.81% (95% CI
24.75-37.22). The prevalence of NAFLD in postmenopausal women was 31.64% (95%
CI 25.82-37.77) in Asia countries compared to 27.99% (95% CI 11.21-48.72) in
Non-Asia countries. Ultrasound was the most commonly used diagnostic technique in
diagnosing NAFLD in postmenopausal women, lead a higher prevalence of NAFLD
(32.77%, 95% CI 27.43-38.35) than computed tomography (CT, 5.64%, 95% CI
4.82-6.52) or fatty live index (FLI, 17.33%, 95% CI 11.72-23.78, P
