IMR Press / CEOG / Volume 48 / Issue 1 / DOI: 10.31083/j.ceog.2021.01.2208
Open Access Review
Prevalence of non-alcoholic fatty liver disease in postmenopausal woman: systematic review and meta-analysis
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1 Department of Obstetrics and Gynecology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 611731 Chengdu, P. R. China
2 Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, P. R. China
*Correspondence: (Li He)
Clin. Exp. Obstet. Gynecol. 2021, 48(1), 24–30;
Submitted: 2 July 2020 | Revised: 23 August 2020 | Accepted: 10 September 2020 | Published: 15 February 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: Non-alcoholic fatty liver disease (NAFLD) has long been considered to be most prevalent chronic hepatic disease. However, the overall prevalence of NAFLD in postmenopausal women was largely unknown. Objectives: In the current study, we aimed to investigate the overall prevalence of NAFLD in postmenopausal women in order to provide more information for clinical work. Methods: A systematic search was conducted in Medline, Embase, web of science and Cochrane for articles in the English language from inception until May 2020. Wilson score method was used to calculate the 95% confidence interval (95% CI) and DerSimonian-Laird random-effects model with Freeman-Tukey double arcsine transformation was used for estimating pooled overall prevalence. Results: Our search returned 4465 records. After removed duplicates and screened titles, abstract and full content of articles, 25 studies were retrieved. Overall, the NAFLD prevalence was 30.81% (95% CI 24.75-37.22). The prevalence of NAFLD in postmenopausal women was 31.64% (95% CI 25.82-37.77) in Asia countries compared to 27.99% (95% CI 11.21-48.72) in Non-Asia countries. Ultrasound was the most commonly used diagnostic technique in diagnosing NAFLD in postmenopausal women, lead a higher prevalence of NAFLD (32.77%, 95% CI 27.43-38.35) than computed tomography (CT, 5.64%, 95% CI 4.82-6.52) or fatty live index (FLI, 17.33%, 95% CI 11.72-23.78, P < 0.01). Conclusion: Approximately one third of postmenopausal women presented with NAFLD indicated a rather high prevalence which call for the attention of primary care physicians, specialists, and health policy makers.

Postmenopausal woman
Fig. 1.
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