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A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males
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1
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Cooper Medical School of Rowan University, Camden, New Jersey, USA
2
Cooper Institute for Reproductive Hormonal Disorders, P.C., Marlton, New Jersey, USA
3
Department Of Obstetrics, Gynecology And Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, Robert Wood Hohnson Univeristy Hospital, New Brunswick, NJ, USA
*Correspondence: laurie@ccivf.com (JEROME H. CHECK)
Clin. Exp. Obstet. Gynecol. 2020, 47(3), 419–420;
https://doi.org/10.31083/j.ceog.2020.03.5078
Submitted: 3 November 2018 | Accepted: 17 November 2018 | Published: 15 June 2020
Copyright: © 2020 Check et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license
https://creativecommons.org/licenses/by/4.0/.
Abstract
Purpose: To determine if exposure to progesterone (P) alone without prior estrogen (E) exposure can cause a rise in serum progesterone induced blocking factor (PIBF). Materials and Methods: Male volunteers received IM progesterone 100 mg for seven days. Baseline and day seven levels of serum P and PIBF were taken. PIBF was measured using a non-commercial newly developed ELISA assay. Results: A significant rise in PIBF was found in male volunteers on day seven. Conclusions: The precipitous rise in serum PIBF in males despite a short exposure to progesterone shows that a person does not need E to induce PIBF secretion by gamma/delta T cells. The possibility still exists pending future studies that E may improve PIBF secretion.
Keywords
Immunomodulatory proteins
Progesterone
Progesterone induced blocking factor (PIBF)
Males
Estrogen