Purpose: To demonstrate that some embryos can be exposed to fire and smoke and still be rescued and result in a healthy baby following embryo transfer. Materials and Methods: Valiant efforts were made to save cleaving embryos by an embryologist and firefighters exposed to a raging fire. Results: Two of three embryos survived the thaw. Initially, there were twins, but eventually a live healthy full-term baby boy was born. Conclusions: Hopefully, no other IVF center will experience a fire catastrophe as described. However, if it does occur, this case report shows that it is worth the effort, and possible risk to staff, to save the embryos despite smoke and heat exposure.