IMR Press / CEOG / Volume 45 / Issue 5 / DOI: 10.12891/ceog4328.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Efficacy and effects of transdermal hormone therapy in postmenopausal women
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1 Climacteric Section, Department of Obstetrics and Gynecology - Federal University of São Paulo – UNIFESP/EPM, Vila Clementino, São Paulo, Brazil
2 Laboratory of Molecular and Structural Gynecology, Hospital das Clínicas, University of São Paulo Faculty of Medicine - FMUSP, Cerqueira Cesar, São Paulo, Brazil
Clin. Exp. Obstet. Gynecol. 2018, 45(5), 735–740; https://doi.org/10.12891/ceog4328.2018
Published: 10 October 2018
Abstract

The authors aimed to evaluate the influence of transdermal hormone therapy (HT) in the blood coagulation parameters. Fifty-eight postmenopausal women received: G1-transdermal estradiol (E2) (50 mg), G2-E2+oral micronized progesterone (100 mg/day), and G3- E2+oral medroxyprogesterone acetate (2.5 mg/day) for six months. Statistical relevance was seen mainly in G1 and G2. G1 showed a decrease in prothrombin time (PT), fibrinogen (FG), and thrombin time (TT) at six months (p < 0.05) compared to baseline values. G2 showed an increase of PT (p < 0.05) and a reduction of activated partial thromboplastin time (aPTT), AT III at three months (p < 0.01). AT III showed an increase after six months (p < 0.05), as well as F1+2 (p < 0.05). G3 exhibited a decrease of PT after three and six months of transdermal HT. Data suggests that E2 alone or E2+OMP are correlated with some variations of anticoagulant and procoagulant factors. E2+MPA avoids any major activation of blood coagulation in patients who receive transdermal HT.
Keywords
Transdermal hormone therapy
Postmenopausal women
17-beta-estradiol
Oral micronized progesterone
Medroxyprogesterone acetate
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