IMR Press / CEOG / Volume 45 / Issue 5 / DOI: 10.12891/ceog4008.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Primary glomerular diseases and pregnancy
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1 Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey
2 Department of Urology, Hacettepe University, Ankara, Turkey
3 Division of Neonatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey
4 Division of Nephrology, Department of Internal Medicine, Hacettepe University, Ankara, Turkey
5 Department of Biostatistics, Hacettepe University, Ankara, Turkey
Clin. Exp. Obstet. Gynecol. 2018, 45(5), 682–686; https://doi.org/10.12891/ceog4008.2018
Published: 10 October 2018
Abstract

Backround: Primary glomerular diseases (PGD) may represent wide spectrum of clinical presentations and pathological findings depending on the histopathological type and the severity/stage of the disease. The severity of PGD-related nephrotic syndrome (NS) predicts pregnancy outcome. The aim of the study to assess whether PGD has any effect on pregnancy and fetal outcome, as well as the effect of pregnancy on PGD. Materials and Methods: Retrospectively, ten pregnant women (11 pregnancies) with PGDs at Hacettepe University were investigated in terms of their pregnancy outcomes. The histopathological diagnosis was focal segmental glomerulosclerosis (FSGS), FSGS superimposed on immunglobulin A ( IgA) nephropathy, membrano-proliferative glomerulonephritis (MPGN), and minimal change disease (MCD). Results: Nearly all pregnancies were complicated by nephrotic “signs and symptoms” and NS to a certain extend (mild-moderate to severe forms) and all cases were delivered by cesarean section. Eight cases (72.7 %) were complicated with IUGR, fetal distress and preterm delivery. Conclusion: In this case series, the authors have demonstrated that PGD has an adverse impact on perinatal outcome.
Keywords
Pregnancy
Primary glomerular disease
Nephrotic syndrome
Perinatal outcome
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