Background: To discuss the epidemic characteristics of syphilis during pregnancy and pregnancy outcomes with perinatal intervention in Jiangyin. Materials and Methods: A retrospective analysis of maternal syphilis cases in Jiangyin from January 2014 to December 2015. Results: Serological screening for syphilis was performed for 25,360 pregnant women cases from 2014 to 2015, and 83 cases with syphilis were identified. The positive rate was 3.27% (83/25,360), the detection rate of syphilis during pregnancy was 78.86% (20,000/25,360), and the standard treatment rate of maternal syphilis was 72.29% (60/83). The epidemiological survey results were as follows: Single-factor analysis showed that age, household registry, occupation, educational level, economic income, number of sexual partners, marital status, and if a sex partner had syphilis influenced whether a pregnant women would be infected with syphilis (p < 0.05). Logistic regression analysis showed that household registry, occupation, educational level, economic income, number of sexual partners, marital status, and whether a sex partner had a syphilis were independent factors for infection (p < 0.05). In 79 newborns whose mothers had syphilis while pregnant, six had congenital syphilis (7.59%), ten had positive titers (12.66%), and 63 (79.75%) were negative for syphilis. With treatment and follow-up, six neonates' clinical symptoms of congenital syphilis disappeared in one month. With preventive treatment, the RPR titers of all the positive newborns became negative in nine months. Conclusions: Pregnancy syphilis remained common among itinerant, low income populations with low education, and infected sexual partners in Jiangyin from 2014 to 2015. In the past two years, the city has paid attention to prevention, screening and treatment, and preliminary results show that the maternal syphilis treatment rate is high and neonatal outcomes have significantly improved. It is necessary to improve screening efforts, strengthen awareness and education, standardize treatment, and improve maternal and neonatal outcomes.