IMR Press / CEOG / Volume 44 / Issue 5 / DOI: 10.12891/ceog4013.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Review
Interventions for treating amniotic fluid embolism: a systematic review with meta-analysis
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1 Complex Operative Unit of Obstetrics and Gynecology, “Alto Tevere” Hospital of Città di Castello, ASL 1 Umbria, Città di Castello, Italy
2 Department of Gynecological, Obstetrical, and Urological Sciences; “Sapienza” University of Rome, Rome, Italy
3 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
Clin. Exp. Obstet. Gynecol. 2017, 44(5), 666–677;
Published: 10 October 2017

Purpose: Assessing to what extent the interventions for treating amniotic fluid embolism (AFE) are effective. Materials and Methods: A systematic review of cases of AFE available on PubMed, Scielo, Scopus, and AJOL databases from 1990 to 2015 was carried out. The perception of effectiveness of each kind of intervention on heart, lungs, coagulopathy, and the importance of immediate parturition was quantified semi-quantitatively, by scoring textual information (from 0 to 3). Scores 2 and 3 were considered positive scores (effective intervention), while 0 and 1 were considered negative scores (ineffective intervention). Rates of such scores were compared with a random distribution of scores from 0 to 3. Sub-groups analyses were carried out. Results: One hundred twenty-one typical AFE cases were assessed. Each intervention for supporting the heart and, predominantly, lung function is perceived as pivotal. Conclusion: The management of AFE should be focused on supporting the lung and the heart function.
Amniotic fluid embolism
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