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Original Research
Cytogenetic analysis of 10,286 cases with male infertility
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1
School of Public Health, Shandong University, Jinan, China
2
Reproductive Hospital Affiliated to Shandong University, Jinan, China
Clin. Exp. Obstet. Gynecol. 2017, 44(3), 392–394;
https://doi.org/10.12891/ceog3245.2017
Published: 10 June 2017
Abstract
Purpose: Chromosome analysis of 10,286 cases with male infertility and to discuss the genetic causes of male infertility. Materials and Methods: 10,286 patients with azoospermia and oligoasthenozoospermia were collected in the present center from January 2009 to January 2013.Peripheral blood lymphocyte culture and chromosome analysis were performed. Results: In all the 10,286 cases with azoospermia and oligoasthenozoospermia, 8,401 cases showed normal karyotype, 538 cases had chromosome polymorphism, accounting for 5.2% and 1,378 cases had chromosomal abnormalities with a frequency of 13.4%; Conclusions: Genetic factors are closely related to the occurrence of azoospermia and oligoasthenozoospermia, and chromosome analysis in patients with male infertility is necessary.
Keywords
Male infertility
Azoospermia
Oligoasthenozoospermia
Chromosomal abnormality