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Case Report
Pregnancies with factor V deficiency: a case report and review of the literature
K. Maeda1, 2, *, T. Kaji2, S. Nakayama2, D. Nakaoku1, M. Murakami1, A. Kondo1, M. Morine1, K. Hinokio1, M. Irahara2
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1
General Perinatal Medical Center, Shikoku Medical Center for Children and Adults, Zentsuji-city, Japan
2
Department of Obstetrics and Gynecology, Tokushima University Hospital, Tokushima, Japan
Clin. Exp. Obstet. Gynecol. 2017, 44(2), 299–300;
https://doi.org/10.12891/ceog3351.2017
Published: 10 April 2017
Abstract
Case report: A 30-year-old Japanese nulliparous woman visited for pregnancy at 33 weeks with a massive ovarian tumor located in the pouch of Douglas. By preoperative screening, her prothrombin time (PT) and activated partial thromboplastin time (APTT) were prolonged, and her FV activity was significantly decreased to 4.8%. After prophylactic FFP 20 ml/kg was administered and her FV factor was 19.3%, cesarean delivery was performed, and her perioperative course was uneventful. One year later, she underwent a dilatation and evacuation because of a missed abortion, although prophylactic FFP was not administered. During a third pregnancy, after prophylactic FFP 20 ml/kg was administered and FV activity increased to 21.1%, elective cesarean delivery was performed, and her postoperative course was uneventful. Conclusion: For surgical therapy or delivery, the goal of therapy is to maintain FV activity above 20%. It is particularly useful to administer prophylactic FFP.
Keywords
Pregnancy
Congenital factor V deficiency
Prophylactic fresh frozen plasma (FFP)
Autosomal recessive disorder