Objectives: This study aimed to analyze relationship of the copper corrosion of copper intrauterine device (TCu220 IUD) and abnormal uterine bleeding. Materials and Methods: Sixty-four patients of abnormal uterine bleeding (too much blood volume, shorten cycle, lengthen period or irregular vaginal bleeding) and 72 cases of normal menstrual cycle and quantity in the present hospital, which were removed of IUD due to non-medical reasons, were enrolled, and 36 regular menstruation cases without placing IUD were selected as control group, in which had assessed in vitro copper ion release of TCu220 IUD and content of copper ions and VEGF in endometrial tissue of each group of women. Results: Daily Cu I UD copper dissolution quantities of abnormal uterine bleeding women was significantly higher than that of regular menstruation women (p < 0.05). Copper ion content and the expression of VEGF in endometrial tissue of abnormal uterine bleeding women was significantly higher than that of regular menstruation women endometrial tissue (p < 0.05), and the endometrial VEGF expression had a positive correlation with copper ion concentration in endometrial tissue. Conclusion: High dissolution quantity of Cu IUD may lead to increase of copper ion content in endometrial tissue and may cause VEGF secretion in the endometrium, and then the occurrence of abnormal uterine bleeding.