Purpose: To report on ten years of intrauterine insemination (IUI) practice at Haseki Training and Research Hospital to determine retrospectively, the impact of IUI on the management of subfertile couples. Materials and Methods: This study was a retrospective analysis of all IUI cycles completed from June 1, 2003, to July 1, 2013, at the Haseki Training and Research Hospital, Istanbul, Turkey. Baseline clinical characteristics, drugs used for ovulation induction, and triggering ovulation were reviewed. The primary outcome was clinical pregnancy. Results: The overall clinical pregnancy rate was 10.2% (26/253). Improved success was significantly associated with a shorter period of infertility (4.8 ± 3.9 years vs 3.2±2.4 years; p = 0.01). Clinical pregnancy rates were significantly higher when recombinant FSH was used for ovulation induction than clomiphene citrate (CC) (22% vs 5.6%; p = 0.002). Patients were also analysed for the drug used for triggering ovulation. The clinical pregnancy rate was 27.2% in the recombinant hCG group compared with 8.6% in the urinary hCG group (p = 0.006). Conclusions: IUI may be a safe and cost-effective option for mild male factor infertility or unexplained infertility. Better results may be obtained when recombinant FSH and recombinant hCG are used and when the duration of infertility is short.