IMR Press / CEOG / Volume 43 / Issue 2 / DOI: 10.12891/ceog3287.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
In vitro fertilization (IVF) outcome in women in overt menopause attempting to induce follicular maturation by follicle stimulating hormone (FSH) receptor down-regulation
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1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology
1 Division of Reproductive Endocrinology & Infertility, Camden, NJ
2 Cooper Institute for Reproductive Hormonal Disorders, P.C., Mt. Laurel, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2016, 43(2), 181–183; https://doi.org/10.12891/ceog3287.2016
Published: 10 April 2016
Abstract

Purpose: To determine the frequency of ovulation induction, obtaining oocytes leading to embryos, and pregnancy rates per embryo transfer in women with premature menopause. Materials and Methods: Prospective observational study of women hoping to have in vitro fertilization-embryo transfer (IVF-ET) with their own oocytes despite being in menopause. Ethinyl estradiol was used to lower follicle stimulation hormone (FSH) and restore sensitivity of follicles to mild FSH stimulation. Results: Three of five women had a live baby. Only one woman failed to induce ovulation and thus failed to have an embryo to transfer. One woman conceived two times and delivered a live healthy baby twice. The live delivered pregnancy rate per transfer was 20% (4/20) with generally one or occasionally two embryos transferred. The pregnancy rate per retrieval was 9.3% (4/43). Conclusions: This data can help other women in this circumstance to decide on IVF with their own eggs or switch to donor eggs.
Keywords
Premature menopause
Embryo transfer
Restoration of FSH receptors
Ethinyl estradiol
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