Objective: The aim of this study was to investigate the correlation of twisting motion phase and infantile spasms in high risk infants. Materials and Methods: One hundred seventy-eight high-risk newborns experiencing follow-up in the rehabilitation phase were selected and full-body motion quality assessment was performed in the twisting motion phase. The occurrence of infants with infantile spasms after 12 months (corrected age) was statistically analyzed. Results: No clear correlation was found between monotonous movement twisting motion phase and infantile spasms, and spasm synchronized movement had no definite prediction for infantile spasms. The incidence of infant spasm with movement form having spastic synchronized characteristics had significant difference compared with monotonous systemic movement (p < 0.01). The sensitivity of predictive rate for spasm-synchronous movement of infantile spasms was 90.9%, the specificity was 96.8%, the positive predictive value was 80%, and the negative predictive value was 98.7%. Conclusions: Spasm synchronized movement had some predictive value for infantile spasms in twisting motion stage. The newborns with this kind of movement form should be checked by regularly ambulatory EEG.