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Original Research
Serum levels of androgens and prostate-specific antigen in endometriosis
M.S. Evsen1,*, M.E. Sak1, H.E. Soydinc1, S. Guven2, S. Basaranoglu1, N.K. Hatipoglu3, O. Evliyaoglu4, T. Gul1
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1
Dicle University, School of Medicine, Department of Obstetrics and Gynecology, Diyarbakir
2
Karadeniz Technical University, School of Medicine, Department of Obstetrics and Gynecology, Trabzon
3
Dicle University, School of Medicine, Department of Urology, Diyarbakir
4
Dicle University, School of Medicine, Department of Medical Biochemistry, Diyarbakir (Turkey)
Clin. Exp. Obstet. Gynecol. 2014, 41(4), 432–435;
https://doi.org/10.12891/ceog16712014
Published: 10 August 2014
Abstract
Objective: The aim of the present study was to evaluate the levels of serum androgens and prostate-specific antigen (PSA) levels in patients with endometriosis. Materials and Methods: Patients with Stage III/IV(advanced stage) endometriosis were compared to controls with respect to basal serum levels of total testosterone (T), free testosterone (fT), androstenedion (A), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulphate (DHEA-S), and PSA in the early follicular phase of menstrual cycle for this prospective case control study. Results: Level of T, fT, A, DHEA, and DHEA-S were higher in patients with endometriosis when compared to control subjects, but the difference was not statistically significant. The mean PSA level was 0.0074 ± 0.0120 ng/ml in patients with endometriosis and 0.0059 ± 0.0056 ng/ml in control group and there was no statistically significant difference between groups (p = 0.58). Conclusion: Serum basal androgens and PSA levels are higher in endometriosis group with respect to control but the differences are not statistically significant.
Keywords
Endometriosis
Androgens
Prostate-specific antigen