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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
C-Met expression pattern in uterine leiomyoma
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1
Anatolia Women's Health Center, Ankara
2
Near East University Faculty of Medicine, Department of Pathology, Nicosia
3
Florence Nightingale Hospital, Department of Pathology, İstanbul
4
Near East University Faculty of Medicine, Department of Obstetrics and Gynecology, Nicosia
5
Florence Nightingale Hospital, Department of Obstetrics and Gynecology, İstanbul (Turkey)
Clin. Exp. Obstet. Gynecol. 2014, 41(3), 254–257;
https://doi.org/10.12891/ceog16812014
Published: 10 June 2014
Abstract
Aim: Growth factors take place in the formation and growth of uterine leiomyomas (LMs). Transforming growth factor beta (TGF-β), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor- 2 (FGF-2), and insulin-like growth factor (IGF) contribute to the pathophysiology of LMs when they bind with a specific membrane receptor and transmit a signal into the cell. Little is known about hepatocyte growth factor (HGF) and its receptor system c-Met in formation and growth of uterine LMs. The aim of this study was to evaluate the c-Met receptor expression on human myometrium and uterine LMs. Materials and Methods: The study was performed on human myometrium and uterine LMs. Expression of c-Met receptor was evaluated by immunohistochemical analysis. Results: Overexpression of c-Met was found in all LM cases and in none of normal myometrium samples c-Met overexpression was seen. Conclusion: HGF and c-Met receptor complex seem to have role in development of uterine LMs.
Keywords
Hepatocyte growth factor
c-Met receptor
Uterine leiomyoma