IMR Press / CEOG / Volume 41 / Issue 1 / DOI: 10.12891/ceog15572014

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Significance of prenatal joint detection of ABO antibody titers and irregular antibodies in pregnant women with type O blood
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1 Department of Blood Transfusion
2 Department of Laboratory Medicine, People's Hospital of Henan Province, Zhengzhou (China)
Clin. Exp. Obstet. Gynecol. 2014, 41(1), 28–31; https://doi.org/10.12891/ceog15572014
Published: 10 February 2014
Abstract

Objective: To investigate the effects of blood transfusion and number of pregnancies on ABO antibody titers and irregular antibodies in pregnant women with type O blood. Materials and Methods: The study included 4,200 pregnant women with type O blood (their husbands were with non-O type blood) that were divided into transfusion group and non-transfusion group, according to whether they had a history of blood transfusion. The both groups were respectively divided into three subgroups (the number of pregnancies was one, two, and ≥ three). The ABO antibody titers and irregular antibodies were detected at the same time. The effects of ABO antibody titers and irregular antibodies on hemolytic disease of the newborn (HDN) were discussed. Results: There was no consistency of ABO antibody titers and existence of irregular antibody. The positive rates of irregular antibody of transfusion group and of the subgroup (number of pregnancies ≥ three) were far higher than that of non-transfusion group and of the subgroups (number of pregnancies < three), respectively. All pregnant women with positive irregular antibody in non-transfusion group were with HDN. Conclusions: For pregnant women with number of pregnancies ≥ three or with history of blood transfusion, the prenatal joint detection of ABO antibody titers and irregular antibodies is helpful for accurately reflecting the in vivo antibody type and level.
Keywords
Antibody titers
Irregular antibodies
Hemolytic disease of the newborn
Blood transfusion
Indirect antiglobulin test
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