IMR Press / CEOG / Volume 40 / Issue 4 / pii/1630389109698-872520005

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Human spermatozoa antigens in unexplained infertility
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1 Department of Obstetrics and Gynecology
2 Department of Histology & Embryology, Hacettepe University, Faculty of Medicine, Ankara
3 Department of Gynecology and Obstetrics, Haseki Training and Research Hospital, Istanbul (Turkey)
Clin. Exp. Obstet. Gynecol. 2013, 40(4), 475–481;
Published: 10 December 2013
Abstract

Objective: To determine and compare the immunolocalization of functionally important antigens in human spermatozoa in an unexplained infertility (UI) group. Materials and Methods: In this study, the sperm samples of 20 patients undergoing evaluation belonging to normozoospermic group, whose primary reason of infertility was under investigation for this purpose, were screened. CD46, CD55 and CD52, CD69, CD98, fMLP, HI307, and 80280 were stained on the spermatozoa through indirect immunofluorescence technique. Results: In addition to CD46, CD55, and CD52 antigens, which are known to be localized on human spermatozoa, significant immunolocalization of several novel antigens including: CD52, CD69, CD98, fMLP, HI307, and 80280 were determined on the spermatozoa of the unexplained infertility group, possibly reflecting important roles in the pathophysiology of such unresolved clinical situations. Conclusion: Identification and characterization of antigens present on sperm cells is crucial for understanding of the diagnosis and treatment of unexplained infertility. Further studies were conducted to evaluate a possible correlation between the expression of these antigens and clinical outcomes in different well-defined infertility groups.
Keywords
Spermatozoa
Surface antigens
Unexplained infertility
Immunofluorescence
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